Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 46039..46303 Replicon plasmid p92
Accession NZ_CP023376
Organism Escherichia coli strain 1283

Toxin (Protein)


Gene name pndA Uniprot ID E6BRV3
Locus tag CNQ51_RS25485 Protein ID WP_001303307.1
Coordinates 46151..46303 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 46039..46101 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ51_RS25470 41278..43569 - 2292 WP_001289276.1 hypothetical protein -
CNQ51_RS25475 43562..44632 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
CNQ51_RS25480 44651..45859 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 46039..46101 - 63 NuclAT_0 - Antitoxin
- 46039..46101 - 63 NuclAT_0 - Antitoxin
- 46039..46101 - 63 NuclAT_0 - Antitoxin
- 46039..46101 - 63 NuclAT_0 - Antitoxin
CNQ51_RS25485 46151..46303 + 153 WP_001303307.1 Hok/Gef family protein Toxin
CNQ51_RS25490 46375..46626 - 252 WP_001291964.1 hypothetical protein -
CNQ51_RS25495 46926..47222 + 297 WP_001275298.1 hypothetical protein -
CNQ51_RS26265 47287..47463 - 177 WP_001054904.1 hypothetical protein -
CNQ51_RS25500 47855..48064 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
CNQ51_RS25505 48136..48798 - 663 WP_000653334.1 plasmid IncI1-type surface exclusion protein ExcA -
CNQ51_RS25510 48863..51025 - 2163 WP_000698351.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..92420 92420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.21 Da        Isoelectric Point: 8.7948

>T81024 WP_001303307.1 NZ_CP023376:46151-46303 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T81024 NZ_CP023376:46151-46303 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT81024 NZ_CP023376:c46101-46039 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A634Q5L1

Antitoxin

Download structure file

References