Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 6487..6751 Replicon plasmid p92
Accession NZ_CP023365
Organism Escherichia coli strain 144

Toxin (Protein)


Gene name pndA Uniprot ID E6BRV3
Locus tag CNQ53_RS26800 Protein ID WP_001303307.1
Coordinates 6487..6639 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 6689..6751 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ53_RS26775 1765..3927 + 2163 WP_000698351.1 DotA/TraY family protein -
CNQ53_RS26780 3992..4654 + 663 WP_000653334.1 plasmid IncI1-type surface exclusion protein ExcA -
CNQ53_RS26785 4726..4935 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
CNQ53_RS27875 5327..5503 + 177 WP_001054904.1 hypothetical protein -
CNQ53_RS26790 5568..5864 - 297 WP_001275298.1 hypothetical protein -
CNQ53_RS26795 6164..6415 + 252 WP_001291964.1 hypothetical protein -
CNQ53_RS26800 6487..6639 - 153 WP_001303307.1 Hok/Gef family protein Toxin
- 6689..6751 + 63 NuclAT_0 - Antitoxin
- 6689..6751 + 63 NuclAT_0 - Antitoxin
- 6689..6751 + 63 NuclAT_0 - Antitoxin
- 6689..6751 + 63 NuclAT_0 - Antitoxin
CNQ53_RS26805 6931..8139 + 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
CNQ53_RS26810 8158..9228 + 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
CNQ53_RS26815 9221..11512 + 2292 WP_001289276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..92421 92421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.21 Da        Isoelectric Point: 8.7948

>T80951 WP_001303307.1 NZ_CP023365:c6639-6487 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T80951 NZ_CP023365:c6639-6487 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT80951 NZ_CP023365:6689-6751 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A634Q5L1

Antitoxin

Download structure file

References