80861

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 48542..48806 Replicon plasmid p95
Accession NZ_CP023356
Organism Escherichia coli strain 746

Toxin (Protein)


Gene name pndA Uniprot ID E6BRV3
Locus tag CNQ56_RS27265 Protein ID WP_001303307.1
Coordinates 48654..48806 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 48542..48604 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ56_RS27250 43781..46072 - 2292 WP_001289276.1 hypothetical protein -
CNQ56_RS27255 46065..47135 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
CNQ56_RS27260 47154..48362 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 48542..48604 - 63 NuclAT_0 - Antitoxin
- 48542..48604 - 63 NuclAT_0 - Antitoxin
- 48542..48604 - 63 NuclAT_0 - Antitoxin
- 48542..48604 - 63 NuclAT_0 - Antitoxin
CNQ56_RS27265 48654..48806 + 153 WP_001303307.1 Hok/Gef family protein Toxin
CNQ56_RS27270 48878..49129 - 252 WP_001291964.1 hypothetical protein -
CNQ56_RS28145 49788..49964 - 177 WP_001054904.1 hypothetical protein -
CNQ56_RS27275 50356..50565 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
CNQ56_RS27280 50637..51287 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
CNQ56_RS27285 51361..53529 - 2169 WP_000698357.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..94881 94881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.21 Da        Isoelectric Point: 8.7948

>T80861 WP_001303307.1 NZ_CP023356:48654-48806 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T80861 NZ_CP023356:48654-48806 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT80861 NZ_CP023356:c48604-48542 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A634Q5L1

Antitoxin

Download structure file

References