73338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2571671..2571873 Replicon chromosome
Accession NZ_CP019857
Organism Clostridioides difficile strain DSM 29745

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag CDIF29745_RS12455 Protein ID WP_004454589.1
Coordinates 2571721..2571873 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 2571671..2571800 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29745_RS12420 2567116..2567433 + 318 WP_009897465.1 hypothetical protein -
CDIF29745_RS12425 2567569..2568033 + 465 WP_009897467.1 hypothetical protein -
CDIF29745_RS12435 2568361..2568522 - 162 WP_004454578.1 hypothetical protein -
CDIF29745_RS20020 2568574..2569388 - 815 Protein_2308 toxin Bro -
CDIF29745_RS19930 2569508..2569696 - 189 WP_004454585.1 hypothetical protein -
CDIF29745_RS12450 2570643..2571527 - 885 WP_009897481.1 hypothetical protein -
- 2571671..2571800 + 130 NuclAT_1 - Antitoxin
CDIF29745_RS12455 2571721..2571873 - 153 WP_004454589.1 hypothetical protein Toxin
CDIF29745_RS12460 2572147..2572470 - 324 WP_009897482.1 hypothetical protein -
CDIF29745_RS12465 2572506..2572760 - 255 WP_004454592.1 hypothetical protein -
CDIF29745_RS12475 2573192..2573710 - 519 Protein_2314 transposase -
CDIF29745_RS12480 2574000..2574373 - 374 Protein_2315 BlaI/MecI/CopY family transcriptional regulator -
CDIF29745_RS12485 2574478..2574852 - 375 WP_004454597.1 BlaI/MecI/CopY family transcriptional regulator -
CDIF29745_RS12490 2575656..2576144 + 489 WP_009897487.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CDIF29745_RS12495 2576533..2576703 + 171 WP_021394397.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2565295..2581952 16657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T73338 WP_004454589.1 NZ_CP019857:c2571873-2571721 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T73338 NZ_CP019857:c2571873-2571721 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT73338 NZ_CP019857:2571671-2571800 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References