69905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1590884..1591325 Replicon chromosome
Accession NZ_CP018401
Organism Burkholderia pseudomallei strain 2013746811

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag BOC51_RS29490 Protein ID WP_009939402.1
Coordinates 1591152..1591325 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag BOC51_RS29485 Protein ID WP_004525420.1
Coordinates 1590884..1591168 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC51_RS29440 1586098..1586844 - 747 WP_151287559.1 VRR-NUC domain-containing protein -
BOC51_RS29445 1586841..1587368 - 528 WP_004552312.1 PAAR domain-containing protein -
BOC51_RS29450 1587647..1587826 + 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin -
BOC51_RS29455 1587871..1588287 + 417 WP_004552310.1 type II toxin-antitoxin system HicB family antitoxin -
BOC51_RS29465 1588716..1589213 - 498 WP_004552308.1 hypothetical protein -
BOC51_RS29470 1589831..1590238 - 408 Protein_1359 DDE-type integrase/transposase/recombinase -
BOC51_RS29485 1590884..1591168 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
BOC51_RS29490 1591152..1591325 - 174 WP_009939402.1 BrnT family toxin Toxin
BOC51_RS29495 1591993..1592268 + 276 WP_025988352.1 hypothetical protein -
BOC51_RS29500 1592278..1592409 + 132 WP_009923452.1 bacteriophage protein Gp48 -
BOC51_RS29510 1592545..1592766 + 222 WP_004525418.1 hypothetical protein -
BOC51_RS38125 1592814..1593032 + 219 WP_004552392.1 hypothetical protein -
BOC51_RS29520 1593207..1593797 - 591 WP_057039349.1 hypothetical protein -
BOC51_RS29525 1594047..1594196 + 150 WP_004537646.1 bacteriophage protein Gp44 -
BOC51_RS29530 1594193..1594966 + 774 Protein_1368 prohibitin family protein -
BOC51_RS38130 1594964..1595368 + 405 Protein_1369 DDE-type integrase/transposase/recombinase -
BOC51_RS29535 1595331..1595759 + 429 Protein_1370 IS110 family transposase -
BOC51_RS29540 1595986..1596102 - 117 Protein_1371 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1568500..1601453 32953
flank IS/Tn - - 1589831..1590151 320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(4-49)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6691.59 Da        Isoelectric Point: 7.9950

>T69905 WP_009939402.1 NZ_CP018401:c1591325-1591152 [Burkholderia pseudomallei]
MSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREVKSYVEQA

Download         Length: 174 bp

>T69905 NZ_CP018401:c1591325-1591152 [Burkholderia pseudomallei]
TTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCGGCGATCGCCTCTATTG
CGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGGGAGGTCAAGAGCTATG
TCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT69905 WP_004525420.1 NZ_CP018401:c1591168-1590884 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp

>AT69905 NZ_CP018401:c1591168-1590884 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGCCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACCGTGCGTTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References