Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2622518..2622720 Replicon chromosome
Accession NZ_CP016318
Organism Clostridioides difficile strain 630 delta erm

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag CDIF630erm_RS20725 Protein ID WP_004454589.1
Coordinates 2622568..2622720 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 2622518..2622647 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630erm_RS12640 2617952..2618416 + 465 WP_011861514.1 hypothetical protein -
CDIF630erm_RS20715 2618744..2618905 - 162 WP_004454578.1 hypothetical protein -
CDIF630erm_RS12655 2618957..2619770 - 814 Protein_2354 toxin Bro -
CDIF630erm_RS20720 2619890..2620042 - 153 WP_021361915.1 hypothetical protein -
CDIF630erm_RS12660 2621451..2622374 - 924 WP_011861517.1 SHOCT domain-containing protein -
- 2622518..2622647 + 130 NuclAT_9 - Antitoxin
CDIF630erm_RS20725 2622568..2622720 - 153 WP_004454589.1 hypothetical protein Toxin
CDIF630erm_RS12670 2622994..2623317 - 324 WP_009897482.1 hypothetical protein -
CDIF630erm_RS12675 2623353..2623607 - 255 WP_004454592.1 hypothetical protein -
CDIF630erm_RS12680 2624043..2624561 - 519 Protein_2360 transposase -
CDIF630erm_RS20430 2624851..2625226 - 376 Protein_2361 BlaI/MecI/CopY family transcriptional regulator -
CDIF630erm_RS12690 2625331..2625708 - 378 WP_011861518.1 BlaI/MecI/CopY family transcriptional regulator -
CDIF630erm_RS12695 2626512..2627006 + 495 WP_011861519.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CDIF630erm_RS20435 2627395..2627565 + 171 WP_004454601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2615678..2631316 15638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T64409 WP_004454589.1 NZ_CP016318:c2622720-2622568 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T64409 NZ_CP016318:c2622720-2622568 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT64409 NZ_CP016318:2622518-2622647 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References