Detailed information of TA system
Overview
TA module
| Type | III | Classification (family/domain) | toxIN/- |
| Location | 62799..63541 | Replicon | plasmid pAW63 |
| Accession | NC_020240 | ||
| Organism | Bacillus thuringiensis serovar kurstaki str. HD73 | ||
Toxin (Protein)
| Gene name | toxN | Uniprot ID | Q3YN09 |
| Locus tag | HD73_7567 | Protein ID | WP_000182254.1 |
| Coordinates | 62799..63383 (-) | Length | 195 a.a. |
Antitoxin (RNA)
| Gene name | toxI | ||
| Locus tag | HD73_7567a | ||
| Coordinates | 63445..63541 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HD73_RS30540 (HD73_7563) | 58204..58650 | - | 447 | WP_001101375.1 | CPBP family intramembrane metalloprotease | - |
| HD73_RS30545 (HD73_7564) | 58680..60821 | - | 2142 | WP_000209240.1 | type IA DNA topoisomerase | - |
| HD73_RS30550 (HD73_7565) | 60943..61323 | - | 381 | WP_000517026.1 | hypothetical protein | - |
| HD73_RS30555 (HD73_7566) | 61430..62731 | - | 1302 | WP_000877084.1 | hypothetical protein | - |
| HD73_RS30560 (HD73_7567) | 62799..63383 | - | 585 | WP_000182254.1 | type III toxin-antitoxin system ToxN/AbiQ family toxin | Toxin |
| - | 63445..63541 | - | 97 | - | - | Antitoxin |
| HD73_RS30565 (HD73_7568) | 63634..64659 | - | 1026 | WP_000437709.1 | DUF3991 and TOPRIM domain-containing protein | - |
| HD73_RS30570 (HD73_7569) | 64739..65290 | - | 552 | WP_000875863.1 | metal-dependent hydrolase | - |
| HD73_RS30575 (HD73_7570) | 65314..66240 | - | 927 | WP_000131507.1 | hypothetical protein | - |
| HD73_RS30580 (HD73_7571) | 66303..67475 | - | 1173 | WP_002134161.1 | hypothetical protein | - |
| HD73_RS30585 (HD73_7572) | 67472..67681 | - | 210 | WP_000082222.1 | DUF5511 family protein | - |
| HD73_RS30590 (HD73_7573) | 67704..68132 | - | 429 | WP_000066903.1 | DUF5514 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Non-Mobilizable plasmid | - | - | 1..71777 | 71777 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 195 a.a. Molecular weight: 22887.13 Da Isoelectric Point: 8.9873
>T6366 WP_000182254.1 NC_020240:c63383-62799 [Bacillus thuringiensis serovar kurstaki str. HD73]
MTNKDNPKFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDEKRIG
VLLVNNMIPVPEKECKEIDIAEKTAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTVQGKPSHKQKFLKGVCCDFP
KLEEKCQEYKERDQAKERDKARRIAYMRQMGRER
MTNKDNPKFHTISTEYIDYLREADSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDEKRIG
VLLVNNMIPVPEKECKEIDIAEKTAADPQYGNLMLKQYLFLKENMDRVTNKVEKVYKDVTVQGKPSHKQKFLKGVCCDFP
KLEEKCQEYKERDQAKERDKARRIAYMRQMGRER
Download Length: 585 bp
>T6366 NC_020240:c63383-62799 [Bacillus thuringiensis serovar kurstaki str. HD73]
TTGACTAATAAAGATAATCCTAAATTTCACACTATTTCAACTGAATATATAGATTATTTAAGAGAAGCGGATAGTAAAGT
ACCTTTTAATAAAGATGAACAGCATAGCAGACCGTATGTAGGTGTATTGGAAAAAATCAATGGTCATGATTATTTTGTAC
CTTTAACATCACGTAACGATAAAAATTTTAACAGTCAGGTCAGTGTAAAGTTATTCGATAATGATGAAAAGCGAATTGGA
GTTTTATTAGTCAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAACAGCAGCAGA
CCCTCAGTATGGTAATTTGATGTTAAAACAGTATTTATTTTTAAAAGAAAATATGGATCGAGTTACTAATAAAGTGGAAA
AAGTATATAAAGATGTAACTGTACAAGGAAAGCCTTCACATAAACAAAAATTCTTAAAAGGAGTTTGTTGTGATTTCCCT
AAATTAGAAGAAAAGTGCCAAGAATATAAAGAAAGAGATCAAGCTAAAGAAAGAGATAAAGCTAGAAGAATAGCATATAT
GCGTCAAATGGGGCGTGAGAGATAA
TTGACTAATAAAGATAATCCTAAATTTCACACTATTTCAACTGAATATATAGATTATTTAAGAGAAGCGGATAGTAAAGT
ACCTTTTAATAAAGATGAACAGCATAGCAGACCGTATGTAGGTGTATTGGAAAAAATCAATGGTCATGATTATTTTGTAC
CTTTAACATCACGTAACGATAAAAATTTTAACAGTCAGGTCAGTGTAAAGTTATTCGATAATGATGAAAAGCGAATTGGA
GTTTTATTAGTCAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAACAGCAGCAGA
CCCTCAGTATGGTAATTTGATGTTAAAACAGTATTTATTTTTAAAAGAAAATATGGATCGAGTTACTAATAAAGTGGAAA
AAGTATATAAAGATGTAACTGTACAAGGAAAGCCTTCACATAAACAAAAATTCTTAAAAGGAGTTTGTTGTGATTTCCCT
AAATTAGAAGAAAAGTGCCAAGAATATAAAGAAAGAGATCAAGCTAAAGAAAGAGATAAAGCTAGAAGAATAGCATATAT
GCGTCAAATGGGGCGTGAGAGATAA
Antitoxin
Download Length: 97 bp
>AT6366 NC_020240:c63541-63445 [Bacillus thuringiensis serovar kurstaki str. HD73]
GTAACCTTACTTTAGTAGGTGCTAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCTAAAAAA
GTAACCTTACTTTAGTAGGTGCTAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCTAAAAAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10071 | Escherichia coli strain CFSAN026791 |
32.222 |
100 |
0.339 |
| T6317 | Pectobacterium atrosepticum |
32.402 |
100 |
0.339 |
| T6365 | Lactococcus lactis |
33.333 |
96.721 |
0.322 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Francesca L Short et al. (2015) A Type III protein-RNA toxin-antitoxin system from Bacillus thuringiensis promotes plasmid retention during spore development. RNA Biology 12(9):933-7. [PubMed:26274022]