Detailed information of TA system
Overview
TA module
| Type | III | Classification (family/domain) | toxIN/- |
| Location | 1706..2473 | Replicon | plasmid pECA1039 |
| Accession | NC_011767 | ||
| Organism | Pectobacterium atrosepticum | ||
Toxin (Protein)
| Gene name | toxN | Uniprot ID | B8X8Z0 |
| Locus tag | pECA1039_03b | Protein ID | WP_012609144.1 |
| Coordinates | 1958..2473 (+) | Length | 172 a.a. |
Antitoxin (RNA)
| Gene name | toxI | ||
| Locus tag | pECA1039_r03a | ||
| Coordinates | 1706..1957 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HS565_RS00005 (pECA1039_01) | 1..489 | - | 489 | WP_176703086.1 | entry exclusion protein 1 | - |
| HS565_RS00010 (pECA1039_02) | 446..643 | + | 198 | WP_012609143.1 | Rop family plasmid primer RNA-binding protein | - |
| - | 1706..1957 | + | 252 | - | - | Antitoxin |
| HS565_RS00020 (pECA1039_03) | 1958..2473 | + | 516 | WP_012609144.1 | type III toxin-antitoxin system ToxN/AbiQ family toxin | Toxin |
| HS565_RS00025 (pECA1039_06) | 2841..3170 | - | 330 | WP_012609147.1 | sigma-70 family RNA polymerase sigma factor | - |
| HS565_RS00050 | 3331..3417 | + | 87 | Protein_5 | DUF1471 domain-containing protein | - |
| HS565_RS00035 | 3794..3949 | + | 156 | WP_072010247.1 | DUF1508 domain-containing protein | - |
| HS565_RS00040 | 3933..4118 | + | 186 | WP_176703089.1 | hypothetical protein | - |
| HS565_RS00045 (pECA1039_09) | 5261..5557 | - | 297 | WP_012609150.1 | VapI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..5620 | 5620 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19701.56 Da Isoelectric Point: 6.2521
>T6317 WP_012609144.1 NC_011767:1958-2473 [Pectobacterium atrosepticum]
MKFYTISSKYIEYLKEFDDKVPNSEDPTYQNPKAFIGIVLEIQGHKYLAPLTSPKKWHNNVKESSLSCFKLHENGVPENQ
LGLINLKFMIPIIEAEVSLLDLGNMPNTPYKRMLYKQLQFIRANSDKIASKSDTLRNLVLQGKMQGTCNFSLLEEKYRDF
GKEAEDTEEGE
MKFYTISSKYIEYLKEFDDKVPNSEDPTYQNPKAFIGIVLEIQGHKYLAPLTSPKKWHNNVKESSLSCFKLHENGVPENQ
LGLINLKFMIPIIEAEVSLLDLGNMPNTPYKRMLYKQLQFIRANSDKIASKSDTLRNLVLQGKMQGTCNFSLLEEKYRDF
GKEAEDTEEGE
Download Length: 516 bp
>T6317 NC_011767:1958-2473 [Pectobacterium atrosepticum]
ATGAAATTCTACACTATATCAAGCAAATACATTGAATATCTAAAGGAATTTGACGACAAGGTTCCCAATAGCGAAGATCC
TACCTACCAAAATCCTAAGGCTTTCATTGGCATAGTATTAGAGATCCAGGGACATAAGTATCTAGCCCCTCTGACATCCC
CAAAAAAGTGGCATAATAATGTTAAAGAGTCATCTCTTAGCTGCTTTAAGCTCCATGAAAACGGCGTGCCCGAAAATCAG
CTTGGATTGATTAACCTGAAGTTCATGATTCCAATAATCGAAGCTGAAGTGTCCTTACTTGATTTGGGCAACATGCCTAA
TACCCCTTACAAGAGAATGCTCTATAAGCAGCTCCAGTTTATTCGTGCAAATTCTGATAAAATAGCTTCAAAATCAGATA
CTTTACGAAACCTCGTATTACAAGGAAAAATGCAAGGAACATGTAATTTTTCCCTGTTAGAAGAAAAATATCGAGATTTC
GGTAAAGAAGCTGAGGATACGGAAGAAGGCGAGTAA
ATGAAATTCTACACTATATCAAGCAAATACATTGAATATCTAAAGGAATTTGACGACAAGGTTCCCAATAGCGAAGATCC
TACCTACCAAAATCCTAAGGCTTTCATTGGCATAGTATTAGAGATCCAGGGACATAAGTATCTAGCCCCTCTGACATCCC
CAAAAAAGTGGCATAATAATGTTAAAGAGTCATCTCTTAGCTGCTTTAAGCTCCATGAAAACGGCGTGCCCGAAAATCAG
CTTGGATTGATTAACCTGAAGTTCATGATTCCAATAATCGAAGCTGAAGTGTCCTTACTTGATTTGGGCAACATGCCTAA
TACCCCTTACAAGAGAATGCTCTATAAGCAGCTCCAGTTTATTCGTGCAAATTCTGATAAAATAGCTTCAAAATCAGATA
CTTTACGAAACCTCGTATTACAAGGAAAAATGCAAGGAACATGTAATTTTTCCCTGTTAGAAGAAAAATATCGAGATTTC
GGTAAAGAAGCTGAGGATACGGAAGAAGGCGAGTAA
Antitoxin
Download Length: 252 bp
>AT6317 NC_011767:1706-1957 [Pectobacterium atrosepticum]
AAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGAT
TTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACC
TTTAAGTGCAGCTAGAAATTCAGGTGATTTACTACCTTTAAGTAATAAAGTAAAAGAGGCGACTACATAGTCGCCTTTTT
TACGAGAAAAAT
AAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGAT
TTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACC
TTTAAGTGCAGCTAGAAATTCAGGTGATTTACTACCTTTAAGTAATAAAGTAAAAGAGGCGACTACATAGTCGCCTTTTT
TACGAGAAAAAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10071 | Escherichia coli strain CFSAN026791 |
82.143 |
98.246 |
0.807 |
| T6366 | Bacillus thuringiensis serovar kurstaki str. HD73 |
32.402 |
100 |
0.339 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Tim R Blower et al. (2012) Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic Acids Research 40(13):6158-73. [PubMed:22434880]
(2) Peter C Fineran et al. (2009) The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. Proceedings of The National Academy of Sciences of The United States of America 106(3):894-9. [PubMed:19124776]
(3) Tim R Blower et al. (2011) A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nature Structural & Molecular Biology 18(2):185-90. [PubMed:21240270]
(4) Francesca L Short et al. (2018) The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity. Scientific Reports 8(1):1013. [PubMed:29343718]