Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type III Classification (family/domain) abiQ-antiQ/-
Location 3504..4162 Replicon plasmid pSRQ900
Accession AF001314
Organism Lactococcus lactis

Toxin (Protein)


Gene name abiQ Uniprot ID -
Locus tag abiQ Protein ID AAC98713.1
Coordinates 3611..4162 (+) Length 184 a.a.

Antitoxin (RNA)


Gene name antiQ
Locus tag antiQ
Coordinates 3504..3602 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Locus_0 271..1431 + 1161 AAC98710.1 RepB -
Locus_1 1428..2015 + 588 AAC98711.1 unknown -
Locus_2 1991..3181 + 1191 AAC98712.2 HsdS -
- 3504..3602 + 99 - - Antitoxin
Locus_3 3611..4162 + 552 AAC98713.1 AbiQ Toxin
Locus_4 4705..6234 + 1530 AAK57817.1 unknown -
Locus_5 6581..6808 + 228 AAK57818.1 unknown -
Locus_6 6810..7091 + 282 AAK57819.1 unknown -
Locus_7 7190..7846 - 657 AAK57820.1 unknown -
Locus_8 7885..8337 - 453 AAK57821.1 unknown -
Locus_9 8464..8844 + 381 AAK57816.1 unknown -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..10836 10836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ToxN/AbiQ toxin

(14-176)


Sequences

Toxin        


Download         Length: 184 a.a.        Molecular weight: 21723.41 Da        Isoelectric Point: 10.1403

>T6365 AAC98713.1 AF001314:3611-4162 [Lactococcus lactis]
MSSFFYKEILRMTLRFFTVTDEYIAYLRKFESKVHYQYENNASTYVGVVLKKNDFNYFIPLSSYKKGNPEKDKAMKKRSR
IVTRLFEIGNINNPLGYLLHHNMIPVPDSELIPLPLDLKKPKHKMMQKQLIYMKSISEKIENKSEVVYRKAAHEKDGYYL
KFSCDFKLLEAKATLYSKKSTFQ

Download         Length: 552 bp

>T6365 AF001314:3611-4162 [Lactococcus lactis]
ATGAGTAGCTTTTTTTATAAGGAGATTTTACGAATGACGTTAAGATTCTTTACTGTAACTGATGAATATATAGCTTATTT
ACGTAAGTTTGAAAGTAAAGTTCATTATCAATATGAAAATAATGCCAGCACTTATGTAGGGGTTGTTTTGAAAAAGAATG
ATTTCAATTACTTTATACCTTTGTCAAGCTACAAAAAGGGGAACCCCGAGAAAGACAAAGCAATGAAAAAAAGAAGTCGA
ATAGTAACTAGACTTTTTGAAATTGGCAATATAAATAATCCTCTTGGATATTTATTACATCATAATATGATTCCAGTTCC
TGACAGCGAATTAATACCCCTACCTTTAGATCTTAAGAAACCTAAACATAAAATGATGCAAAAACAACTAATTTATATGA
AAAGTATCAGCGAAAAAATTGAAAATAAATCTGAAGTGGTATATAGAAAAGCTGCTCATGAAAAAGATGGATATTACTTA
AAATTTTCCTGTGATTTTAAACTACTAGAAGCTAAAGCAACATTATATTCTAAGAAATCTACATTTCAATAA

Antitoxin


Download         Length: 99 bp

>AT6365 AF001314:3504-3602 [Lactococcus lactis]
TATCCAAGCCATAGTTGGAATTGATAAAATTGGAGTATCCAAGCCATAGTTGGAATTGATAAAATTGGAGTATCCAAGCC
ATAGTTGGAATTGATAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T6366 Bacillus thuringiensis serovar kurstaki str. HD73

33.333

96.721

0.322
T10071 Escherichia coli strain CFSAN026791

30.409

100

0.304

Multiple sequence alignment    


Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References

(1) Julie E Samson et al. (2013) Structure and activity of AbiQ, a lactococcal endoribonuclease belonging to the type III toxin-antitoxin system. Molecular Microbiology 87(4):756-68. [PubMed:23279123] 3D_structure


3D_structure protein structure literature