Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/- |
| Location | 1759537..1760173 | Replicon | chromosome |
| Accession | NC_011593 | ||
| Organism | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | W6EZW1 |
| Locus tag | BLON_RS08335 | Protein ID | WP_014484977.1 |
| Coordinates | 1759817..1760173 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | D6PAX1 |
| Locus tag | BLON_RS08330 | Protein ID | WP_012577921.1 |
| Coordinates | 1759537..1759830 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BLON_RS08305 (Blon_1601) | 1754609..1755064 | - | 456 | WP_012577916.1 | Holliday junction resolvase RuvX | - |
| BLON_RS08310 (Blon_1602) | 1755073..1757751 | - | 2679 | WP_012577917.1 | alanine--tRNA ligase | - |
| BLON_RS14535 (Blon_1603) | 1757880..1758116 | - | 237 | WP_012577918.1 | hypothetical protein | - |
| BLON_RS08320 (Blon_1604) | 1758116..1758514 | - | 399 | WP_012577919.1 | DUF948 domain-containing protein | - |
| BLON_RS08325 (Blon_1605) | 1758597..1759280 | - | 684 | WP_012577920.1 | histidine phosphatase family protein | - |
| BLON_RS08330 (Blon_1606) | 1759537..1759830 | + | 294 | WP_012577921.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| BLON_RS08335 (Blon_1607) | 1759817..1760173 | + | 357 | WP_014484977.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| BLON_RS08340 (Blon_1608) | 1760350..1760952 | - | 603 | WP_012577923.1 | transglutaminase family protein | - |
| BLON_RS08345 (Blon_1609) | 1761057..1761413 | - | 357 | WP_012577924.1 | SdpI family protein | - |
| BLON_RS08350 (Blon_1610) | 1761506..1761946 | + | 441 | WP_012577925.1 | cytidine deaminase | - |
| BLON_RS08355 (Blon_1611) | 1762129..1762911 | + | 783 | WP_012577926.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| BLON_RS08360 (Blon_1612) | 1763090..1763716 | - | 627 | WP_007052130.1 | 30S ribosomal protein S4 | - |
| BLON_RS08365 (Blon_1613) | 1763915..1764907 | - | 993 | WP_012577927.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13302.25 Da Isoelectric Point: 8.9603
>T6259 WP_014484977.1 NC_011593:1759817-1760173 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA
Download Length: 357 bp
>T6259 NC_011593:1759817-1760173 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGATGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGATGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10866.31 Da Isoelectric Point: 4.2896
>AT6259 WP_012577921.1 NC_011593:1759537-1759830 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED
MAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED
Download Length: 294 bp
>AT6259 NC_011593:1759537-1759830 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCATGGG
GTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCGTCC
GCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCCCAG
ATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA
ATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCATGGG
GTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCGTCC
GCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCCCAG
ATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6258 | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 |
44.118 |
86.441 |
0.381 |
| T10011 | Bifidobacterium ruminantium strain An807 An807_NODE_4_length_147701_cov_109.271 |
37.374 |
92.523 |
0.346 |
| T10162 | Nitrosomonas europaea ATCC 19718 |
30.973 |
97.414 |
0.302 |
| T655 | Leptospira interrogans serovar Lai str. 56601 |
30.357 |
99.115 |
0.301 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6258 | Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 |
33.696 |
97.872 |
0.33 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0L7D489 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S2VTZ6 |
References
(1) Olga Averina et al. (2015) Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697. Anaerobe 35(Pt B):59-67. [PubMed:26210151]