Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 38817..39352 Replicon plasmid unnamed1
Accession NZ_CP013024
Organism Escherichia coli strain 2009C-3133

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag MJ49_RS00220 Protein ID WP_000222775.1
Coordinates 39065..39352 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag MJ49_RS00215 Protein ID WP_001139207.1
Coordinates 38817..39068 (+) Length 84 a.a.

Genomic Context

MJ49_RS00205MJ49_RS00215MJ49_RS00220MJ49_RS32660MJ49_RS00240MJ49_RS00190MJ49_RS00195MJ49_RS00200MJ49_RS00235
Location: 36996..37868 (873 bp)
Type: Others
Protein ID: WP_000729440.1
Location: 38817..39068 (252 bp)
Type: Antitoxin
Protein ID: WP_001139207.1
Location: 39065..39352 (288 bp)
Type: Toxin
Protein ID: WP_000222775.1
Location: 39362..39907 (546 bp)
Type: Others
Protein ID: WP_000926984.1
Location: 41515..41754 (240 bp)
Type: Others
Protein ID: Protein_46
Location: 33959..34579 (621 bp)
Type: Others
Protein ID: WP_000176497.1
Location: 34846..35511 (666 bp)
Type: Others
Protein ID: WP_000154143.1
Location: 35652..36293 (642 bp)
Type: Others
Protein ID: WP_000335846.1
Location: 40559..41161 (603 bp)
Type: Others
Protein ID: WP_000517694.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MJ49_RS0019033959..34579-621WP_000176497.1DUF1449 family protein-
MJ49_RS0019534846..35511-666WP_000154143.1hypothetical protein-
MJ49_RS0020035652..36293-642WP_000335846.1transcription termination factor NusG-
MJ49_RS0020536996..37868+873WP_000729440.1incFII family plasmid replication initiator RepA-
MJ49_RS0021538817..39068+252WP_001139207.1plasmid stabilization proteinAntitoxin
MJ49_RS0022039065..39352+288WP_000222775.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MJ49_RS3266039362..39907+546WP_000926984.1hypothetical protein-
MJ49_RS0023540559..41161-603WP_000517694.1hypothetical protein-
MJ49_RS0024041515..41754+240Protein_46hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideConjugative plasmidblaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(A)-1..120611120611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T57718 WP_000222775.1 NZ_CP013024:39065-39352 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T57718 NZ_CP013024:39065-39352 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGAGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT57718 WP_001139207.1 NZ_CP013024:38817-39068 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT57718 NZ_CP013024:38817-39068 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBT2HS21

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A754EQ65

References