57701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 833260..834044 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag AP033_RS03750 Protein ID WP_001114075.1
Coordinates 833775..834044 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag AP033_RS03745 Protein ID WP_000921691.1
Coordinates 833260..833781 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AP033_RS03720 830186..830599 - 414 WP_000049420.1 VOC family protein -
AP033_RS03725 830783..831298 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
AP033_RS03730 831492..831776 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AP033_RS03735 831773..832051 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
AP033_RS03740 832190..832585 - 396 WP_001000868.1 hypothetical protein -
AP033_RS19770 832836..832961 - 126 WP_001905700.1 DUF645 family protein -
AP033_RS03745 833260..833781 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
AP033_RS03750 833775..834044 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
AP033_RS19775 834075..834179 - 105 WP_099607150.1 acetyltransferase -
AP033_RS03755 834236..834835 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
AP033_RS03760 834985..835857 - 873 WP_000254717.1 DUF3800 domain-containing protein -
AP033_RS03765 836032..836250 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
AP033_RS03770 836314..836751 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
AP033_RS03775 836870..837079 - 210 Protein_732 GNAT family N-acetyltransferase -
AP033_RS03780 837215..837604 - 390 WP_001081302.1 hypothetical protein -
AP033_RS03785 837779..838021 - 243 WP_000107462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 836314..836751 437
- inside Integron - - 829699..942463 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T57701 WP_001114075.1 NZ_CP013013:c834044-833775 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T57701 NZ_CP013013:c834044-833775 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT57701 WP_000921691.1 NZ_CP013013:c833781-833260 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT57701 NZ_CP013013:c833781-833260 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References