Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2649826..2650028 Replicon chromosome
Accession NZ_CP010905
Organism Clostridioides difficile 630

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag CDIF630_RS20565 Protein ID WP_004454589.1
Coordinates 2649876..2650028 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 2649826..2649955 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630_RS12755 2645260..2645724 + 465 WP_011861514.1 hypothetical protein -
CDIF630_RS20555 2646052..2646213 - 162 WP_004454578.1 hypothetical protein -
CDIF630_RS12770 2646265..2647078 - 814 Protein_2374 toxin Bro -
CDIF630_RS20560 2647198..2647350 - 153 WP_021361915.1 hypothetical protein -
CDIF630_RS12775 2648759..2649682 - 924 WP_011861517.1 SHOCT domain-containing protein -
- 2649826..2649955 + 130 NuclAT_9 - Antitoxin
CDIF630_RS20565 2649876..2650028 - 153 WP_004454589.1 hypothetical protein Toxin
CDIF630_RS12785 2650302..2650625 - 324 WP_009897482.1 hypothetical protein -
CDIF630_RS12790 2650661..2650915 - 255 WP_004454592.1 hypothetical protein -
CDIF630_RS12795 2651351..2651869 - 519 Protein_2380 transposase -
CDIF630_RS20280 2652159..2652534 - 376 Protein_2381 BlaI/MecI/CopY family transcriptional regulator -
CDIF630_RS12805 2652639..2653016 - 378 WP_011861518.1 BlaI/MecI/CopY family transcriptional regulator -
CDIF630_RS12810 2653820..2654314 + 495 WP_011861519.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CDIF630_RS20285 2654703..2654873 + 171 WP_004454601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2642986..2663210 20224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T53087 WP_004454589.1 NZ_CP010905:c2650028-2649876 [Clostridioides difficile 630]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T53087 NZ_CP010905:c2650028-2649876 [Clostridioides difficile 630]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT53087 NZ_CP010905:2649826-2649955 [Clostridioides difficile 630]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References