Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 3076077..3076279 Replicon chromosome
Accession NZ_CP010888
Organism Clostridioides difficile strain 08ACD0030

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag TW87_RS14615 Protein ID WP_004454589.1
Coordinates 3076127..3076279 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 3076077..3076206 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TW87_RS14585 3071326..3071643 + 318 WP_009897465.1 hypothetical protein -
TW87_RS14590 3071779..3072243 + 465 WP_004454576.1 hypothetical protein -
TW87_RS14595 3072572..3072733 - 162 WP_004454578.1 hypothetical protein -
TW87_RS20030 3072785..3073599 - 815 Protein_2776 toxin Bro -
TW87_RS20035 3073719..3073871 - 153 WP_009897477.1 hypothetical protein -
TW87_RS14610 3075010..3075933 - 924 WP_021364626.1 SHOCT domain-containing protein -
- 3076077..3076206 + 130 NuclAT_3 - Antitoxin
TW87_RS14615 3076127..3076279 - 153 WP_004454589.1 hypothetical protein Toxin
TW87_RS14620 3076553..3076876 - 324 WP_021364628.1 hypothetical protein -
TW87_RS14625 3076912..3077166 - 255 WP_004454592.1 hypothetical protein -
TW87_RS14630 3077598..3078116 - 519 Protein_2782 transposase -
TW87_RS19905 3078406..3078780 - 375 Protein_2783 BlaI/MecI/CopY family transcriptional regulator -
TW87_RS14640 3078885..3079262 - 378 WP_021364350.1 BlaI/MecI/CopY family transcriptional regulator -
TW87_RS14645 3080067..3080561 + 495 WP_021364347.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
TW87_RS19910 3080950..3081120 + 171 WP_021416406.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3069505..3086369 16864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T53035 WP_004454589.1 NZ_CP010888:c3076279-3076127 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

>T53035 NZ_CP010888:c3076279-3076127 [Clostridioides difficile]
ATGGATAATTTTTTATTTAATGTGTTAGCTAGTGTAACAGCTAGTTACATAGTTTATTTGATTAGCAAGTTAATCAAAAA
AGTAAAAAGCCACTCTACCGCAAAGAGTGACTTAAAGATTGATATAAATTTTAAATATCATCGTAAAAAATAA

Antitoxin


Download         Length: 130 bp

>AT53035 NZ_CP010888:3076077-3076206 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References