Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD-PIN |
| Location | 2013440..2014155 | Replicon | chromosome |
| Accession | NC_010278 | ||
| Organism | Actinobacillus pleuropneumoniae serovar 3 str. JL03 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | APJL_1864 | Protein ID | WP_012263404.1 |
| Coordinates | 2013440..2013868 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | B0BT01 |
| Locus tag | APJL_1865 | Protein ID | WP_005599447.1 |
| Coordinates | 2013868..2014155 (-) | Length | 96 a.a. |
Genomic Context
Location: 2014361..2016076 (1716 bp)
Type: Others
Protein ID: WP_012263406.1
Type: Others
Protein ID: WP_012263406.1
Location: 2017003..2017959 (957 bp)
Type: Others
Protein ID: WP_012263408.1
Type: Others
Protein ID: WP_012263408.1
Location: 2017959..2018552 (594 bp)
Type: Others
Protein ID: WP_005599453.1
Type: Others
Protein ID: WP_005599453.1
Location: 2009025..2010731 (1707 bp)
Type: Others
Protein ID: WP_005606484.1
Type: Others
Protein ID: WP_005606484.1
Location: 2010827..2011108 (282 bp)
Type: Others
Protein ID: WP_012263402.1
Type: Others
Protein ID: WP_012263402.1
Location: 2011235..2013316 (2082 bp)
Type: Others
Protein ID: WP_012263403.1
Type: Others
Protein ID: WP_012263403.1
Location: 2013440..2013868 (429 bp)
Type: Toxin
Protein ID: WP_012263404.1
Type: Toxin
Protein ID: WP_012263404.1
Location: 2013868..2014155 (288 bp)
Type: Antitoxin
Protein ID: WP_005599447.1
Type: Antitoxin
Protein ID: WP_005599447.1
Location: 2016142..2016330 (189 bp)
Type: Others
Protein ID: WP_005602684.1
Type: Others
Protein ID: WP_005602684.1
Location: 2016333..2016914 (582 bp)
Type: Others
Protein ID: WP_012263407.1
Type: Others
Protein ID: WP_012263407.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| APJL_RS09410 (APJL_1861) | 2009025..2010731 | - | 1707 | WP_005606484.1 | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | - |
| APJL_RS09415 (APJL_1862) | 2010827..2011108 | - | 282 | WP_012263402.1 | DNA-directed RNA polymerase subunit omega | - |
| APJL_RS09420 (APJL_1863) | 2011235..2013316 | - | 2082 | WP_012263403.1 | ATP-dependent DNA helicase RecG | - |
| APJL_RS09425 (APJL_1864) | 2013440..2013868 | - | 429 | WP_012263404.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| APJL_RS09430 (APJL_1865) | 2013868..2014155 | - | 288 | WP_005599447.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| APJL_RS09435 (APJL_1867) | 2014361..2016076 | + | 1716 | WP_012263406.1 | proline--tRNA ligase | - |
| APJL_RS09440 (APJL_1868) | 2016142..2016330 | - | 189 | WP_005602684.1 | hypothetical protein | - |
| APJL_RS09445 (APJL_1869) | 2016333..2016914 | - | 582 | WP_012263407.1 | sigma-70 family RNA polymerase sigma factor | - |
| APJL_RS09450 (APJL_1870) | 2017003..2017959 | + | 957 | WP_012263408.1 | protein-methionine-sulfoxide reductase catalytic subunit MsrP | - |
| APJL_RS09455 (APJL_1871) | 2017959..2018552 | + | 594 | WP_005599453.1 | sulfoxide reductase heme-binding subunit YedZ | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 16495.92 Da Isoelectric Point: 7.7945
>T4923 WP_012263404.1 NC_010278:c2013868-2013440 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MFQYLFDTNIISELYKLGNSRIDTNVRQWLETIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQA
KSFSINNEIALLASEYHIPNKMDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN
MFQYLFDTNIISELYKLGNSRIDTNVRQWLETIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQA
KSFSINNEIALLASEYHIPNKMDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN
Download Length: 429 bp
>T4923 NC_010278:c2013868-2013440 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGTTTCAATATCTTTTTGATACCAACATCATTTCCGAGCTTTATAAGCTAGGAAACAGTAGAATAGATACCAATGTACG
ACAATGGTTAGAAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAATAAAAACGGGGATTTTAC
TTAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTATTAAGCGTTTATCAAGCT
AAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAAATGGATTTAAACGATGC
TTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTTCAACTGTTGCGATATAC
GTTTATTTAATCCTTTCGAACCGAATTAA
ATGTTTCAATATCTTTTTGATACCAACATCATTTCCGAGCTTTATAAGCTAGGAAACAGTAGAATAGATACCAATGTACG
ACAATGGTTAGAAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAATAAAAACGGGGATTTTAC
TTAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTATTAAGCGTTTATCAAGCT
AAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAAATGGATTTAAACGATGC
TTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTTCAACTGTTGCGATATAC
GTTTATTTAATCCTTTCGAACCGAATTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 11040.29 Da Isoelectric Point: 4.5578
>AT4923 WP_005599447.1 NC_010278:c2014155-2013868 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE
Download Length: 288 bp
>AT4923 NC_010278:c2014155-2013868 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T4250 | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 | 33.088 | 100 | 0.354 |
| T6113 | Synechocystis sp. PCC 6803 | 35.461 | 99.296 | 0.352 |
| T10034 | Thermus thermophilus HB27 | 31.25 | 100 | 0.326 |
| T843 | Bradyrhizobium diazoefficiens USDA 110 | 31.206 | 100 | 0.312 |
Showing 1 to 4 of 4 rows
Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10033 | Thermus thermophilus HB27 | 29.655 | 100 | 0.312 |
Showing 1 to 1 of 1 rows
Multiple sequence alignment
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| No matching records found | ||
Antitoxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A3N3C5 |
References
(1) Chengkun Zheng et al. (2017) Identification of four type II toxin-antitoxin systems in Actinobacillus pleuropneumoniae. FEMS Microbiology Letters 364(12):10.1093/femsle/fnx126. [PubMed:28637172]