48504

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1619287..1619927 Replicon chromosome
Accession NZ_CP009164
Organism Burkholderia pseudomallei A79A

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag X996_RS06475 Protein ID WP_009893919.1
Coordinates 1619748..1619927 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q63NA5
Locus tag X996_RS06470 Protein ID WP_004552310.1
Coordinates 1619287..1619703 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X996_RS41130 1614475..1614606 + 132 WP_009923452.1 bacteriophage protein Gp48 -
X996_RS06440 1614742..1614963 + 222 WP_038759295.1 hypothetical protein -
X996_RS40400 1614930..1615229 + 300 WP_161788725.1 hypothetical protein -
X996_RS06450 1615460..1616041 - 582 WP_004542548.1 hypothetical protein -
X996_RS06455 1616297..1616446 + 150 WP_004537646.1 bacteriophage protein Gp44 -
X996_RS40900 1616443..1617216 + 774 Protein_1278 prohibitin family protein -
X996_RS41135 1617214..1617642 + 429 Protein_1279 DDE-type integrase/transposase/recombinase -
X996_RS06465 1618361..1618858 + 498 WP_004552308.1 hypothetical protein -
X996_RS06470 1619287..1619703 - 417 WP_004552310.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
X996_RS06475 1619748..1619927 - 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
X996_RS06480 1620207..1620440 + 234 Protein_1283 PAAR domain-containing protein -
X996_RS06485 1620674..1621201 + 528 WP_004552312.1 PAAR domain-containing protein -
X996_RS06490 1621198..1621932 + 735 WP_004552313.1 VRR-NUC domain-containing protein -
X996_RS06495 1621942..1623057 + 1116 WP_009893924.1 DUF3396 domain-containing protein -
X996_RS06500 1623128..1623703 - 576 WP_004552315.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1605968..1639550 33582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T48504 WP_009893919.1 NZ_CP009164:c1619927-1619748 [Burkholderia pseudomallei A79A]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T48504 NZ_CP009164:c1619927-1619748 [Burkholderia pseudomallei A79A]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGCCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15120.06 Da        Isoelectric Point: 4.7025

>AT48504 WP_004552310.1 NZ_CP009164:c1619703-1619287 [Burkholderia pseudomallei A79A]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGEDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT48504 NZ_CP009164:c1619703-1619287 [Burkholderia pseudomallei A79A]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GAGAAGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTCGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
PDB 6G1C
PDB 6G1N
PDB 6G26
AlphaFold DB Q63NA5

References