48466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 405056..405696 Replicon chromosome
Accession NZ_CP009150
Organism Burkholderia pseudomallei B03

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag X995_RS01625 Protein ID WP_009893919.1
Coordinates 405056..405235 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q63NA5
Locus tag X995_RS01630 Protein ID WP_004552310.1
Coordinates 405280..405696 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X995_RS01600 401280..401855 + 576 WP_004552315.1 recombinase family protein -
X995_RS01605 401926..403041 - 1116 WP_009893924.1 DUF3396 domain-containing protein -
X995_RS01610 403051..403785 - 735 WP_004552313.1 VRR-NUC domain-containing protein -
X995_RS01615 403782..404309 - 528 WP_004552312.1 PAAR domain-containing protein -
X995_RS01620 404543..404776 - 234 Protein_316 PAAR domain-containing protein -
X995_RS01625 405056..405235 + 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
X995_RS01630 405280..405696 + 417 WP_004552310.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
X995_RS01635 406125..406622 - 498 WP_004552308.1 hypothetical protein -
X995_RS41065 407341..407769 - 429 Protein_320 DDE-type integrase/transposase/recombinase -
X995_RS40835 407767..408540 - 774 Protein_321 prohibitin family protein -
X995_RS01645 408537..408686 - 150 WP_004537646.1 bacteriophage protein Gp44 -
X995_RS01650 408942..409523 + 582 WP_004542548.1 hypothetical protein -
X995_RS40250 409754..410053 - 300 WP_161788725.1 hypothetical protein -
X995_RS01660 410020..410241 - 222 WP_038759295.1 hypothetical protein -
X995_RS41070 410377..410508 - 132 WP_009923452.1 bacteriophage protein Gp48 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 385433..415372 29939


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T48466 WP_009893919.1 NZ_CP009150:405056-405235 [Burkholderia pseudomallei B03]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T48466 NZ_CP009150:405056-405235 [Burkholderia pseudomallei B03]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGCCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15120.06 Da        Isoelectric Point: 4.7025

>AT48466 WP_004552310.1 NZ_CP009150:405280-405696 [Burkholderia pseudomallei B03]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGEDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT48466 NZ_CP009150:405280-405696 [Burkholderia pseudomallei B03]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GAGAAGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTCGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
PDB 6G1C
PDB 6G1N
PDB 6G26
AlphaFold DB Q63NA5

References