Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1806..2341 Replicon plasmid pE2863-1
Accession NZ_AP018803
Organism Escherichia coli strain E2863

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag EL381_RS27275 Protein ID WP_000222775.1
Coordinates 2054..2341 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag EL381_RS27270 Protein ID WP_001139207.1
Coordinates 1806..2057 (+) Length 84 a.a.

Genomic Context

EL381_RS30010EL381_RS27270EL381_RS27275EL381_RS30220EL381_RS27310EL381_RS27300
Location: 1552..1719 (168 bp)
Type: Others
Protein ID: WP_000841010.1
Location: 1806..2057 (252 bp)
Type: Antitoxin
Protein ID: WP_001139207.1
Location: 2054..2341 (288 bp)
Type: Toxin
Protein ID: WP_000222775.1
Location: 2351..2896 (546 bp)
Type: Others
Protein ID: WP_000926984.1
Location: 4504..4743 (240 bp)
Type: Others
Protein ID: Protein_6
Location: 3548..4150 (603 bp)
Type: Others
Protein ID: WP_000517694.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL381_RS300101552..1719+168WP_000841010.1hypothetical protein-
EL381_RS272701806..2057+252WP_001139207.1plasmid stabilization proteinAntitoxin
EL381_RS272752054..2341+288WP_000222775.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EL381_RS302202351..2896+546WP_000926984.1hypothetical protein-
EL381_RS273003548..4150-603WP_000517694.1hypothetical protein-
EL381_RS273104504..4743+240Protein_6hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideConjugative plasmidblaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(A)-1..124261124261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T32350 WP_000222775.1 NZ_AP018803:2054-2341 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T32350 NZ_AP018803:2054-2341 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGAGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT32350 WP_001139207.1 NZ_AP018803:1806-2057 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT32350 NZ_AP018803:1806-2057 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBT2HS21

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A754EQ65

References