31952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 1520951..1521498 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag V060002_RS07345 Protein ID WP_000229317.1
Coordinates 1520951..1521253 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag V060002_RS07350 Protein ID WP_000861987.1
Coordinates 1521241..1521498 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07305 1516114..1516218 - 105 WP_099607150.1 acetyltransferase -
V060002_RS07310 1516275..1516874 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
V060002_RS07315 1517024..1517896 - 873 WP_000254716.1 DUF3800 domain-containing protein -
V060002_RS07320 1518071..1518289 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
V060002_RS07325 1518353..1518790 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
V060002_RS07330 1518909..1519118 - 210 Protein_1355 GNAT family N-acetyltransferase -
V060002_RS07335 1519254..1519643 - 390 WP_001081302.1 hypothetical protein -
V060002_RS07340 1519800..1520717 - 918 WP_000186333.1 alpha/beta hydrolase -
V060002_RS07345 1520951..1521253 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
V060002_RS07350 1521241..1521498 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
V060002_RS07360 1521700..1522233 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
V060002_RS19480 1522230..1522655 - 426 WP_001882332.1 DUF1778 domain-containing protein -
V060002_RS07370 1522722..1523093 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
V060002_RS07375 1523234..1523521 - 288 WP_000426470.1 hypothetical protein -
V060002_RS07380 1523673..1524341 - 669 WP_000043871.1 hypothetical protein -
V060002_RS07385 1524572..1524844 + 273 WP_000246253.1 DUF1778 domain-containing protein -
V060002_RS07390 1524841..1525338 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
V060002_RS07400 1525540..1525692 - 153 WP_001884520.1 DUF645 family protein -
V060002_RS07405 1526014..1526469 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
flank IS/Tn - - 1518353..1518790 437
- inside Integron - - 1511738..1563819 52081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T31952 WP_000229317.1 NZ_AP018677:c1521253-1520951 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T31952 NZ_AP018677:c1521253-1520951 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT31952 WP_000861987.1 NZ_AP018677:c1521498-1521241 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT31952 NZ_AP018677:c1521498-1521241 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References