Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 1520951..1521498 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag V060002_RS07345 Protein ID WP_000229317.1
Coordinates 1520951..1521253 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag V060002_RS07350 Protein ID WP_000861987.1
Coordinates 1521241..1521498 (-) Length 86 a.a.

Genomic Context

V060002_RS07385V060002_RS07390V060002_RS07305V060002_RS07310V060002_RS07315V060002_RS07320V060002_RS07325V060002_RS07330V060002_RS07335V060002_RS07340V060002_RS07345V060002_RS07350V060002_RS07360V060002_RS19480V060002_RS07370V060002_RS07375V060002_RS07380V060002_RS07400V060002_RS07405
Location: 1524572..1524844 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 1524841..1525338 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 1516114..1516218 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 1516275..1516874 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 1517024..1517896 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 1518071..1518289 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 1518353..1518790 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 1518909..1519118 (210 bp)
Type: Others
Protein ID: Protein_1355
Location: 1519254..1519643 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 1519800..1520717 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 1520951..1521253 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 1521241..1521498 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 1521700..1522233 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 1522230..1522655 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 1522722..1523093 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 1523234..1523521 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 1523673..1524341 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 1525540..1525692 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 1526014..1526469 (456 bp)
Type: Others
Protein ID: WP_001245327.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
V060002_RS073051516114..1516218-105WP_099607150.1acetyltransferase-
V060002_RS073101516275..1516874-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
V060002_RS073151517024..1517896-873WP_000254716.1DUF3800 domain-containing protein-
V060002_RS073201518071..1518289-219WP_071908318.1GNAT family N-acetyltransferase-
V060002_RS073251518353..1518790-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
V060002_RS073301518909..1519118-210Protein_1355GNAT family N-acetyltransferase-
V060002_RS073351519254..1519643-390WP_001081302.1hypothetical protein-
V060002_RS073401519800..1520717-918WP_000186333.1alpha/beta hydrolase-
V060002_RS073451520951..1521253-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
V060002_RS073501521241..1521498-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
V060002_RS073601521700..1522233-534WP_000118351.1GNAT family N-acetyltransferase-
V060002_RS194801522230..1522655-426WP_001882332.1DUF1778 domain-containing protein-
V060002_RS073701522722..1523093-372WP_001164080.1nucleotide pyrophosphohydrolase-
V060002_RS073751523234..1523521-288WP_000426470.1hypothetical protein-
V060002_RS073801523673..1524341-669WP_000043871.1hypothetical protein-
V060002_RS073851524572..1524844+273WP_000246253.1DUF1778 domain-containing protein-
V060002_RS073901524841..1525338+498WP_000982260.1GNAT family N-acetyltransferase-
V060002_RS074001525540..1525692-153WP_001884520.1DUF645 family protein-
V060002_RS074051526014..1526469-456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-1516275..1622843106568
flankIS/Tn--1518353..1518790437
-insideIntegron--1511738..156381952081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T31952 WP_000229317.1 NZ_AP018677:c1521253-1520951 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T31952 NZ_AP018677:c1521253-1520951 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT31952 WP_000861987.1 NZ_AP018677:c1521498-1521241 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT31952 NZ_AP018677:c1521498-1521241 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References