Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2622519..2622721 Replicon chromosome
Accession NZ_LN614756
Organism Clostridioides difficile strain 630Derm

Toxin (Protein)


Gene name CD2299.1 Uniprot ID Q185H1
Locus tag CD630DERM_RS21000 Protein ID WP_004454589.1
Coordinates 2622569..2622721 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ1641
Locus tag -
Coordinates 2622519..2622648 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD630DERM_RS12420 2617953..2618417 + 465 WP_011861514.1 hypothetical protein -
CD630DERM_RS20990 2618745..2618906 - 162 WP_004454578.1 hypothetical protein -
CD630DERM_RS20280 2618958..2619771 - 814 Protein_2353 toxin Bro -
CD630DERM_RS20995 2619891..2620043 - 153 WP_021361915.1 hypothetical protein -
CD630DERM_RS12440 2621452..2622375 - 924 WP_011861517.1 SHOCT domain-containing protein -
- 2622519..2622648 + 130 NuclAT_9 - Antitoxin
CD630DERM_RS21000 2622569..2622721 - 153 WP_004454589.1 hypothetical protein Toxin
CD630DERM_RS12450 2622995..2623318 - 324 WP_009897482.1 hypothetical protein -
CD630DERM_RS12455 2623354..2623608 - 255 WP_004454592.1 hypothetical protein -
CD630DERM_RS12460 2624044..2624562 - 519 Protein_2359 transposase -
CD630DERM_RS20695 2624852..2625227 - 376 Protein_2360 BlaI/MecI/CopY family transcriptional regulator -
CD630DERM_RS12470 2625332..2625709 - 378 WP_011861518.1 BlaI/MecI/CopY family transcriptional regulator -
CD630DERM_RS12475 2626513..2627007 + 495 WP_011861519.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CD630DERM_RS20700 2627396..2627566 + 171 WP_004454601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2615679..2631317 15638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.92 Da        Isoelectric Point: 10.6365

>T285471 WP_004454589.1 NZ_LN614756:c2622721-2622569 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Download         Length: 153 bp

Antitoxin


Download         Length: 130 bp

>AT285471 NZ_LN614756:2622519-2622648 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V725

Antitoxin

Download structure file

References