Detailed information of TA system TA285471

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2622519..2622721
• Replicon: chromosome
• Accession: NZ_LN614756
• Organism: Clostridioides difficile strain 630Derm

Toxin (Protein)

• Gene name: CD2299.1
• Uniprot ID: Q185H1
• Locus tag: CD630DERM_RS21000
• Protein ID: WP_004454589.1
• Coordinates: 2622569..2622721 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ1641
Locus tag	-
Coordinates	2622519..2622648 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CD630DERM_RS12420	2617953..2618417	+	465	WP_011861514.1	hypothetical protein	-
CD630DERM_RS20990	2618745..2618906	-	162	WP_004454578.1	hypothetical protein	-
CD630DERM_RS20280	2618958..2619771	-	814	Protein_2353	toxin Bro	-
CD630DERM_RS20995	2619891..2620043	-	153	WP_021361915.1	hypothetical protein	-
CD630DERM_RS12440	2621452..2622375	-	924	WP_011861517.1	SHOCT domain-containing protein	-
-	2622519..2622648	+	130	NuclAT_9	-	Antitoxin
CD630DERM_RS21000	2622569..2622721	-	153	WP_004454589.1	hypothetical protein	Toxin
CD630DERM_RS12450	2622995..2623318	-	324	WP_009897482.1	hypothetical protein	-
CD630DERM_RS12455	2623354..2623608	-	255	WP_004454592.1	hypothetical protein	-
CD630DERM_RS12460	2624044..2624562	-	519	Protein_2359	transposase	-
CD630DERM_RS20695	2624852..2625227	-	376	Protein_2360	BlaI/MecI/CopY family transcriptional regulator	-
CD630DERM_RS12470	2625332..2625709	-	378	WP_011861518.1	BlaI/MecI/CopY family transcriptional regulator	-
CD630DERM_RS12475	2626513..2627007	+	495	WP_011861519.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
CD630DERM_RS20700	2627396..2627566	+	171	WP_004454601.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_009089 Clostridium difficile 630 Prophage TA010176 2658361..2675497 0.002	inside	Prophage	-	-	2615679..2631317	15638

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5817.92 Da
• Isoelectric Point: 10.6365

>T285471 WP_004454589.1 NZ_LN614756:c2622721-2622569 [Clostridioides difficile]
MDNFLFNVLASVTASYIVYLISKLIKKVKSHSTAKSDLKIDINFKYHRKK

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 130 bp

>AT285471 NZ_LN614756:2622519-2622648 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGCGGTAGAGTGAAGTTCTATAACTGAAAGTTATTTTTTACGATGATATTTAAAATTTAT
ATCAATCTTTAAGTCACTCTTTGCGGTAGAGTGGCTTTTTACTTTTTTGA

Structures

Toxin

• AlphaFold DB: A0A125V725

Antitoxin