28047

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 105096..105630 Replicon plasmid pLELO
Accession NC_018141
Organism Legionella pneumophila subsp. pneumophila str. Lorraine

Toxin (Protein)


Gene name relE Uniprot ID A0A7G4RL39
Locus tag LPO_RS16230 Protein ID WP_014845122.1
Coordinates 105349..105630 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G4RL40
Locus tag LPO_RS16225 Protein ID WP_014845121.1
Coordinates 105096..105356 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPO_RS17355 100428..100583 - 156 WP_154080667.1 hypothetical protein -
LPO_RS16545 100655..101146 + 492 WP_051009158.1 IS91 family transposase -
LPO_RS16550 (LPO_p0111) 101168..101701 + 534 WP_061637559.1 IS91 family transposase -
LPO_RS16200 (LPO_p0113) 102067..102459 + 393 Protein_108 methyltransferase domain-containing protein -
LPO_RS16205 (LPO_p0114) 102897..103217 - 321 WP_014845117.1 type II toxin-antitoxin system PemK/MazF family toxin -
LPO_RS16210 (LPO_p0115) 103204..103437 - 234 WP_014845118.1 hypothetical protein -
LPO_RS16215 (LPO_p0117) 103546..103893 - 348 WP_080031944.1 WGR domain-containing protein -
LPO_RS16220 (LPO_p0118) 103999..104883 - 885 WP_014845120.1 recombinase family protein -
LPO_RS16225 (LPO_p0119) 105096..105356 + 261 WP_014845121.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LPO_RS16230 (LPO_p0120) 105349..105630 + 282 WP_014845122.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LPO_RS16235 (LPO_p0121) 105810..108308 - 2499 WP_014845123.1 DEAD/DEAH box helicase family protein -
LPO_RS16240 (LPO_p0122) 108357..108647 - 291 WP_014845124.1 helix-turn-helix domain-containing protein -
LPO_RS16245 (LPO_p0123) 108625..108978 - 354 WP_014845125.1 type II toxin-antitoxin system RelE/ParE family toxin -
LPO_RS16250 (LPO_p0124) 109017..109835 - 819 WP_014845126.1 hypothetical protein -
LPO_RS16255 (LPO_p0125) 109888..110211 - 324 WP_014845127.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-29 - 1..150432 150432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.69 Da        Isoelectric Point: 8.9816

>T28047 WP_014845122.1 NC_018141:105349-105630 [Legionella pneumophila subsp. pneumophila]
MLELELATQFKRDLKKITKQGKRRTLLDSIVEQLQKEEPLDPKHKDHSLSVNWDGYRECHITPDWLLIYKTIKDDRIQLL
RLSRTGSHSDLFG

Download         Length: 282 bp

>T28047 NC_018141:105349-105630 [Legionella pneumophila subsp. pneumophila]
ATGCTTGAATTAGAGTTGGCGACACAGTTTAAGCGTGATTTGAAAAAGATTACGAAGCAAGGGAAAAGAAGGACGCTCTT
AGACTCTATTGTAGAGCAATTGCAAAAGGAAGAACCCCTGGATCCAAAGCATAAGGATCACAGTCTTTCCGTAAATTGGG
ATGGTTATCGTGAATGTCACATTACCCCCGATTGGTTATTAATTTATAAGACCATTAAAGATGATCGCATACAATTGCTG
CGATTATCACGAACAGGATCACATAGTGATTTGTTTGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9594.08 Da        Isoelectric Point: 6.9803

>AT28047 WP_014845121.1 NC_018141:105096-105356 [Legionella pneumophila subsp. pneumophila]
MNKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKETREAMAELESGKGERFKTMKDVW
DSVDNA

Download         Length: 261 bp

>AT28047 NC_018141:105096-105356 [Legionella pneumophila subsp. pneumophila]
ATGAATAAGGCGGCAACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCAGAAGCGATTTTGCATAAGGTAGG
CTTATCTACAGCCGAGGCGATTCGACTGTTCTATAGCCAGGTCTGTCTCCAAAATGGCCTGCCTTTTGAGGTAAAAATAC
CGAACAAAGAGACAAGAGAGGCCATGGCAGAGCTGGAATCAGGAAAAGGCGAGCGATTTAAAACAATGAAGGATGTATGG
GATTCTGTAGATAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G4RL39

Antitoxin

Source ID Structure
AlphaFold DB A0A7G4RL40

References