76395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 98430..98964 Replicon 1 (D-7475) plasmid unnamed1
Accession NZ_CP021284
Organism Legionella pneumophila subsp. pneumophila strain Allentown

Toxin (Protein)


Gene name relE Uniprot ID A0A7G4RL39
Locus tag CA921_RS16040 Protein ID WP_014845122.1
Coordinates 98683..98964 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G4RL40
Locus tag CA921_RS16035 Protein ID WP_014845121.1
Coordinates 98430..98690 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA921_RS16710 93762..93917 - 156 WP_154080667.1 hypothetical protein -
CA921_RS16000 93989..94480 + 492 WP_051009158.1 IS91 family transposase -
CA921_RS16005 94502..95035 + 534 WP_061637559.1 IS91 family transposase -
CA921_RS16010 95401..95793 + 393 Protein_100 methyltransferase domain-containing protein -
CA921_RS16015 96231..96551 - 321 WP_014845117.1 type II toxin-antitoxin system PemK/MazF family toxin -
CA921_RS16020 96538..96771 - 234 WP_014845118.1 hypothetical protein -
CA921_RS16025 96880..97227 - 348 WP_080031944.1 WGR domain-containing protein -
CA921_RS16030 97333..98217 - 885 WP_014845120.1 recombinase family protein -
CA921_RS16035 98430..98690 + 261 WP_014845121.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CA921_RS16040 98683..98964 + 282 WP_014845122.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CA921_RS16045 99144..101642 - 2499 WP_014845123.1 DEAD/DEAH box helicase family protein -
CA921_RS16050 101691..101981 - 291 WP_014845124.1 helix-turn-helix domain-containing protein -
CA921_RS16055 101959..102312 - 354 WP_014845125.1 type II toxin-antitoxin system RelE/ParE family toxin -
CA921_RS16060 102351..103169 - 819 WP_014845126.1 hypothetical protein -
CA921_RS16065 103222..103545 - 324 WP_014845127.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-29 - 1..150433 150433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.69 Da        Isoelectric Point: 8.9816

>T76395 WP_014845122.1 NZ_CP021284:98683-98964 [Legionella pneumophila subsp. pneumophila]
MLELELATQFKRDLKKITKQGKRRTLLDSIVEQLQKEEPLDPKHKDHSLSVNWDGYRECHITPDWLLIYKTIKDDRIQLL
RLSRTGSHSDLFG

Download         Length: 282 bp

>T76395 NZ_CP021284:98683-98964 [Legionella pneumophila subsp. pneumophila]
ATGCTTGAATTAGAGTTGGCGACACAGTTTAAGCGTGATTTGAAAAAGATTACGAAGCAAGGGAAAAGAAGGACGCTCTT
AGACTCTATTGTAGAGCAATTGCAAAAGGAAGAACCCCTGGATCCAAAGCATAAGGATCACAGTCTTTCCGTAAATTGGG
ATGGTTATCGTGAATGTCACATTACCCCCGATTGGTTATTAATTTATAAGACCATTAAAGATGATCGCATACAATTGCTG
CGATTATCACGAACAGGATCACATAGTGATTTGTTTGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9594.08 Da        Isoelectric Point: 6.9803

>AT76395 WP_014845121.1 NZ_CP021284:98430-98690 [Legionella pneumophila subsp. pneumophila]
MNKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKETREAMAELESGKGERFKTMKDVW
DSVDNA

Download         Length: 261 bp

>AT76395 NZ_CP021284:98430-98690 [Legionella pneumophila subsp. pneumophila]
ATGAATAAGGCGGCAACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCAGAAGCGATTTTGCATAAGGTAGG
CTTATCTACAGCCGAGGCGATTCGACTGTTCTATAGCCAGGTCTGTCTCCAAAATGGCCTGCCTTTTGAGGTAAAAATAC
CGAACAAAGAGACAAGAGAGGCCATGGCAGAGCTGGAATCAGGAAAAGGCGAGCGATTTAAAACAATGAAGGATGTATGG
GATTCTGTAGATAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G4RL39

Antitoxin

Source ID Structure
AlphaFold DB A0A7G4RL40

References