53379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 95309..95843 Replicon plasmid unnamed
Accession NZ_CP011106
Organism Legionella pneumophila strain L10-023 isolate Ulm

Toxin (Protein)


Gene name relE Uniprot ID A0A7G4RL39
Locus tag ULM_RS16965 Protein ID WP_014845122.1
Coordinates 95562..95843 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G4RL40
Locus tag ULM_RS16960 Protein ID WP_014845121.1
Coordinates 95309..95569 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ULM_RS18015 90643..90798 - 156 WP_154080667.1 hypothetical protein -
ULM_RS16925 90870..91361 + 492 WP_051009158.1 IS91 family transposase -
ULM_RS16930 91383..91916 + 534 WP_061637559.1 IS91 family transposase -
ULM_RS16935 92282..92674 + 393 Protein_100 methyltransferase domain-containing protein -
ULM_RS16940 93111..93431 - 321 WP_014845117.1 type II toxin-antitoxin system PemK/MazF family toxin -
ULM_RS16945 93418..93651 - 234 WP_014845118.1 hypothetical protein -
ULM_RS16950 93759..94106 - 348 WP_080031944.1 WGR domain-containing protein -
ULM_RS16955 94212..95096 - 885 WP_014845120.1 recombinase family protein -
ULM_RS16960 95309..95569 + 261 WP_014845121.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ULM_RS16965 95562..95843 + 282 WP_014845122.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ULM_RS16970 96023..98521 - 2499 WP_014845123.1 DEAD/DEAH box helicase family protein -
ULM_RS16975 98570..98860 - 291 WP_014845124.1 helix-turn-helix domain-containing protein -
ULM_RS16980 98838..99191 - 354 WP_014845125.1 type II toxin-antitoxin system RelE/ParE family toxin -
ULM_RS16985 99230..100048 - 819 WP_014845126.1 hypothetical protein -
ULM_RS16990 100101..100424 - 324 WP_014845127.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-29 - 1..143694 143694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.69 Da        Isoelectric Point: 8.9816

>T53379 WP_014845122.1 NZ_CP011106:95562-95843 [Legionella pneumophila]
MLELELATQFKRDLKKITKQGKRRTLLDSIVEQLQKEEPLDPKHKDHSLSVNWDGYRECHITPDWLLIYKTIKDDRIQLL
RLSRTGSHSDLFG

Download         Length: 282 bp

>T53379 NZ_CP011106:95562-95843 [Legionella pneumophila]
ATGCTTGAATTAGAGTTGGCGACACAGTTTAAGCGTGATTTGAAAAAGATTACGAAGCAAGGGAAAAGAAGGACGCTCTT
AGACTCTATTGTAGAGCAATTGCAAAAGGAAGAACCCCTGGATCCAAAGCATAAGGATCACAGTCTTTCCGTAAATTGGG
ATGGTTATCGTGAATGTCACATTACCCCCGATTGGTTATTAATTTATAAGACCATTAAAGATGATCGCATACAATTGCTG
CGATTATCACGAACAGGATCACATAGTGATTTGTTTGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9594.08 Da        Isoelectric Point: 6.9803

>AT53379 WP_014845121.1 NZ_CP011106:95309-95569 [Legionella pneumophila]
MNKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKETREAMAELESGKGERFKTMKDVW
DSVDNA

Download         Length: 261 bp

>AT53379 NZ_CP011106:95309-95569 [Legionella pneumophila]
ATGAATAAGGCGGCAACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCAGAAGCGATTTTGCATAAGGTAGG
CTTATCTACAGCCGAGGCGATTCGACTGTTCTATAGCCAGGTCTGTCTCCAAAATGGCCTGCCTTTTGAGGTAAAAATAC
CGAACAAAGAGACAAGAGAGGCCATGGCAGAGCTGGAATCAGGAAAAGGCGAGCGATTTAAAACAATGAAGGATGTATGG
GATTCTGTAGATAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G4RL39

Antitoxin

Source ID Structure
AlphaFold DB A0A7G4RL40

References