Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4091653..4092194 Replicon chromosome
Accession NZ_CP117001
Organism Escherichia coli strain MLI108K2

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag NL410_RS21790 Protein ID WP_000615983.1
Coordinates 4091653..4091931 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag NL410_RS21795 Protein ID WP_000729703.1
Coordinates 4091934..4092194 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL410_RS21775 (4089235) 4089235..4089813 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
NL410_RS21780 (4090019) 4090019..4090786 + 768 WP_000333380.1 class II glutamine amidotransferase -
NL410_RS21785 (4090757) 4090757..4091497 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NL410_RS21790 (4091653) 4091653..4091931 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NL410_RS21795 (4091934) 4091934..4092194 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NL410_RS21800 (4092404) 4092404..4093153 + 750 WP_000056849.1 C40 family peptidase -
NL410_RS21805 (4093329) 4093329..4093826 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
NL410_RS21810 (4094050) 4094050..4095762 - 1713 Protein_3909 flagellar biosynthesis protein FlhA -
NL410_RS21815 (4095734) 4095734..4096519 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - gmhA/lpcA 4083934..4099894 15960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T269725 WP_000615983.1 NZ_CP117001:c4091931-4091653 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT269725 WP_000729703.1 NZ_CP117001:c4092194-4091934 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References