Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4091017..4091558 Replicon chromosome
Accession NZ_CP116994
Organism Escherichia coli strain MLI108K1

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag NL409_RS21775 Protein ID WP_000615983.1
Coordinates 4091017..4091295 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag NL409_RS21780 Protein ID WP_000729703.1
Coordinates 4091298..4091558 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL409_RS21760 (4088599) 4088599..4089177 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
NL409_RS21765 (4089383) 4089383..4090150 + 768 WP_000333380.1 class II glutamine amidotransferase -
NL409_RS21770 (4090121) 4090121..4090861 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NL409_RS21775 (4091017) 4091017..4091295 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NL409_RS21780 (4091298) 4091298..4091558 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NL409_RS21785 (4091768) 4091768..4092517 + 750 WP_000056849.1 C40 family peptidase -
NL409_RS21790 (4092693) 4092693..4093190 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
NL409_RS21795 (4093414) 4093414..4095126 - 1713 Protein_3906 flagellar biosynthesis protein FlhA -
NL409_RS21800 (4095098) 4095098..4095883 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - gmhA/lpcA 4083298..4099258 15960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T269694 WP_000615983.1 NZ_CP116994:c4091295-4091017 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT269694 WP_000729703.1 NZ_CP116994:c4091558-4091298 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References