Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 989110..989651 Replicon chromosome
Accession NZ_CP104114
Organism Escherichia coli strain USDA-ARS-USMARC-51408

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag N1706_RS04590 Protein ID WP_000615983.1
Coordinates 989110..989388 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag N1706_RS04595 Protein ID WP_000729703.1
Coordinates 989391..989651 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1706_RS04575 (986692) 986692..987270 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
N1706_RS04580 (987476) 987476..988243 + 768 WP_000333380.1 class II glutamine amidotransferase -
N1706_RS04585 (988214) 988214..988954 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N1706_RS04590 (989110) 989110..989388 - 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N1706_RS04595 (989391) 989391..989651 - 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N1706_RS04600 (989861) 989861..990610 + 750 WP_000056849.1 C40 family peptidase -
N1706_RS04605 (990786) 990786..991283 + 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
N1706_RS04610 (991507) 991507..993219 - 1713 Protein_879 flagellar biosynthesis protein FlhA -
N1706_RS04615 (993191) 993191..993976 + 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - gmhA/lpcA 981391..997351 15960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T257219 WP_000615983.1 NZ_CP104114:c989388-989110 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT257219 WP_000729703.1 NZ_CP104114:c989651-989391 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References