Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1726297..1726924 Replicon chromosome
Accession NC_013508
Organism Edwardsiella tarda EIB202

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag ETAE_RS07665 Protein ID WP_015871332.1
Coordinates 1726595..1726924 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ETAE_RS07660 Protein ID WP_005286394.1
Coordinates 1726297..1726605 (-) Length 103 a.a.

Genomic Context

ETAE_RS17320ETAE_RS07625ETAE_RS07630ETAE_RS07635ETAE_RS07640ETAE_RS18200ETAE_RS07645ETAE_RS07650ETAE_RS17330ETAE_RS07670ETAE_RS07675ETAE_RS07680ETAE_RS07685ETAE_RS07690ETAE_RS07695ETAE_RS07620ETAE_RS07655ETAE_RS07660ETAE_RS07665
Location: 1722129..1722344 (216 bp)
Type: Others
Protein ID: WP_012848463.1
Location: 1722442..1722798 (357 bp)
Type: Others
Protein ID: WP_012848464.1
Location: 1722795..1723028 (234 bp)
Type: Others
Protein ID: WP_005286423.1
Location: 1723060..1723311 (252 bp)
Type: Others
Protein ID: WP_012848465.1
Location: 1723514..1724230 (717 bp)
Type: Others
Protein ID: Protein_1518
Location: 1724228..1724512 (285 bp)
Type: Others
Protein ID: Protein_1519
Location: 1724515..1724817 (303 bp)
Type: Others
Protein ID: WP_012848467.1
Location: 1725106..1725351 (246 bp)
Type: Others
Protein ID: WP_012848468.1
Location: 1725332..1725607 (276 bp)
Type: Others
Protein ID: WP_080514633.1
Location: 1727345..1727992 (648 bp)
Type: Others
Protein ID: Protein_1526
Location: 1728164..1728502 (339 bp)
Type: Others
Protein ID: WP_012848472.1
Location: 1728505..1729056 (552 bp)
Type: Others
Protein ID: WP_012848473.1
Location: 1729192..1730028 (837 bp)
Type: Others
Protein ID: WP_080514635.1
Location: 1730131..1730676 (546 bp)
Type: Others
Protein ID: WP_041692512.1
Location: 1731033..1731809 (777 bp)
Type: Others
Protein ID: WP_012848476.1
Location: 1721332..1722024 (693 bp)
Type: Others
Protein ID: WP_041692511.1
Location: 1725690..1726202 (513 bp)
Type: Others
Protein ID: WP_012848469.1
Location: 1726297..1726605 (309 bp)
Type: Antitoxin
Protein ID: WP_005286394.1
Location: 1726595..1726924 (330 bp)
Type: Toxin
Protein ID: WP_015871332.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ETAE_RS076201721332..1722024-693WP_041692511.1helix-turn-helix transcriptional regulator-
ETAE_RS17320 (ETAE_1615)1722129..1722344+216WP_012848463.1helix-turn-helix domain-containing protein-
ETAE_RS07625 (ETAE_1616)1722442..1722798+357WP_012848464.1hypothetical protein-
ETAE_RS07630 (ETAE_1617)1722795..1723028+234WP_005286423.1hypothetical protein-
ETAE_RS07635 (ETAE_1618)1723060..1723311+252WP_012848465.1hypothetical protein-
ETAE_RS07640 (ETAE_1619)1723514..1724230+717Protein_1518helix-turn-helix domain-containing protein-
ETAE_RS182001724228..1724512+285Protein_1519DUF1367 family protein-
ETAE_RS07645 (ETAE_1620)1724515..1724817+303WP_012848467.1DUF1364 domain-containing protein-
ETAE_RS07650 (ETAE_1621)1725106..1725351+246WP_012848468.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ETAE_RS173301725332..1725607+276WP_080514633.1Txe/YoeB family addiction module toxin-
ETAE_RS07655 (ETAE_1622)1725690..1726202-513WP_012848469.1DUF2442 domain-containing protein-
ETAE_RS07660 (ETAE_1623)1726297..1726605-309WP_005286394.1helix-turn-helix transcriptional regulatorAntitoxin
ETAE_RS076651726595..1726924-330WP_015871332.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ETAE_RS07670 (ETAE_1625)1727345..1727992+648Protein_1526hypothetical protein-
ETAE_RS07675 (ETAE_1626)1728164..1728502+339WP_012848472.1phage holin, lambda family-
ETAE_RS07680 (ETAE_1627)1728505..1729056+552WP_012848473.1glycoside hydrolase family 108 protein-
ETAE_RS07685 (ETAE_1628)1729192..1730028+837WP_080514635.1antA/AntB antirepressor family protein-
ETAE_RS076901730131..1730676+546WP_041692512.1DUF2514 family protein-
ETAE_RS07695 (ETAE_1630)1731033..1731809+777WP_012848476.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1698905..174495746052


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T24429 WP_015871332.1 NC_013508:c1726924-1726595 [Edwardsiella tarda EIB202]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T24429 NC_013508:c1726924-1726595 [Edwardsiella tarda EIB202]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11233.90 Da        Isoelectric Point: 8.5371

>AT24429 WP_005286394.1 NC_013508:c1726605-1726297 [Edwardsiella tarda EIB202]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT24429 NC_013508:c1726605-1726297 [Edwardsiella tarda EIB202]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCCGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGCCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A411H7J1

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References