Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1726297..1726924 | Replicon | chromosome |
| Accession | NC_013508 | ||
| Organism | Edwardsiella tarda EIB202 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A411H7J1 |
| Locus tag | ETAE_RS07665 | Protein ID | WP_015871332.1 |
| Coordinates | 1726595..1726924 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | ETAE_RS07660 | Protein ID | WP_005286394.1 |
| Coordinates | 1726297..1726605 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETAE_RS07620 | 1721332..1722024 | - | 693 | WP_041692511.1 | helix-turn-helix transcriptional regulator | - |
| ETAE_RS17320 (ETAE_1615) | 1722129..1722344 | + | 216 | WP_012848463.1 | helix-turn-helix domain-containing protein | - |
| ETAE_RS07625 (ETAE_1616) | 1722442..1722798 | + | 357 | WP_012848464.1 | hypothetical protein | - |
| ETAE_RS07630 (ETAE_1617) | 1722795..1723028 | + | 234 | WP_005286423.1 | hypothetical protein | - |
| ETAE_RS07635 (ETAE_1618) | 1723060..1723311 | + | 252 | WP_012848465.1 | hypothetical protein | - |
| ETAE_RS07640 (ETAE_1619) | 1723514..1724230 | + | 717 | Protein_1518 | helix-turn-helix domain-containing protein | - |
| ETAE_RS18200 | 1724228..1724512 | + | 285 | Protein_1519 | DUF1367 family protein | - |
| ETAE_RS07645 (ETAE_1620) | 1724515..1724817 | + | 303 | WP_012848467.1 | DUF1364 domain-containing protein | - |
| ETAE_RS07650 (ETAE_1621) | 1725106..1725351 | + | 246 | WP_012848468.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| ETAE_RS17330 | 1725332..1725607 | + | 276 | WP_080514633.1 | Txe/YoeB family addiction module toxin | - |
| ETAE_RS07655 (ETAE_1622) | 1725690..1726202 | - | 513 | WP_012848469.1 | DUF2442 domain-containing protein | - |
| ETAE_RS07660 (ETAE_1623) | 1726297..1726605 | - | 309 | WP_005286394.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| ETAE_RS07665 | 1726595..1726924 | - | 330 | WP_015871332.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ETAE_RS07670 (ETAE_1625) | 1727345..1727992 | + | 648 | Protein_1526 | hypothetical protein | - |
| ETAE_RS07675 (ETAE_1626) | 1728164..1728502 | + | 339 | WP_012848472.1 | phage holin, lambda family | - |
| ETAE_RS07680 (ETAE_1627) | 1728505..1729056 | + | 552 | WP_012848473.1 | glycoside hydrolase family 108 protein | - |
| ETAE_RS07685 (ETAE_1628) | 1729192..1730028 | + | 837 | WP_080514635.1 | antA/AntB antirepressor family protein | - |
| ETAE_RS07690 | 1730131..1730676 | + | 546 | WP_041692512.1 | DUF2514 family protein | - |
| ETAE_RS07695 (ETAE_1630) | 1731033..1731809 | + | 777 | WP_012848476.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 1698905..1744957 | 46052 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12771.78 Da Isoelectric Point: 9.6247
>T24429 WP_015871332.1 NC_013508:c1726924-1726595 [Edwardsiella tarda EIB202]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
Download Length: 330 bp
>T24429 NC_013508:c1726924-1726595 [Edwardsiella tarda EIB202]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11233.90 Da Isoelectric Point: 8.5371
>AT24429 WP_005286394.1 NC_013508:c1726605-1726297 [Edwardsiella tarda EIB202]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
Download Length: 309 bp
>AT24429 NC_013508:c1726605-1726297 [Edwardsiella tarda EIB202]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCCGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGCCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCCGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGCCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|