229787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1071545..1072193 Replicon chromosome
Accession NZ_CP089948
Organism Streptococcus pneumoniae TIGR4

Toxin (Protein)


Gene name higB Uniprot ID A0A0H2UQ08
Locus tag LXA46_RS05355 Protein ID WP_000551587.1
Coordinates 1071545..1071910 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0H2UQ20
Locus tag LXA46_RS05360 Protein ID WP_000794247.1
Coordinates 1071900..1072193 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXA46_RS05315 (LXA46_05305) 1066784..1067401 + 618 WP_000424676.1 Rha family transcriptional regulator -
LXA46_RS05320 (LXA46_05310) 1067436..1067888 + 453 WP_000141102.1 hypothetical protein -
LXA46_RS05325 (LXA46_05315) 1067885..1068331 + 447 WP_000171242.1 DnaD domain protein -
LXA46_RS05330 (LXA46_05320) 1068343..1069227 + 885 WP_000838905.1 ATP-binding protein -
LXA46_RS05335 (LXA46_05325) 1069476..1070126 + 651 WP_000138311.1 hypothetical protein -
LXA46_RS05340 (LXA46_05330) 1070173..1070601 + 429 WP_000918210.1 hypothetical protein -
LXA46_RS05345 (LXA46_05335) 1070609..1070920 + 312 WP_001113833.1 hypothetical protein -
LXA46_RS05350 (LXA46_05340) 1070938..1071348 + 411 WP_000162610.1 hypothetical protein -
LXA46_RS05355 (LXA46_05345) 1071545..1071910 + 366 WP_000551587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXA46_RS05360 (LXA46_05350) 1071900..1072193 + 294 WP_000794247.1 helix-turn-helix transcriptional regulator Antitoxin
LXA46_RS05365 (LXA46_05355) 1072211..1073401 + 1191 WP_000123149.1 hypothetical protein -
LXA46_RS05370 (LXA46_05360) 1073404..1073580 + 177 WP_000346914.1 hypothetical protein -
LXA46_RS05375 (LXA46_05365) 1073900..1074346 - 447 WP_061631657.1 tyrosine-type recombinase/integrase -
LXA46_RS05380 (LXA46_05370) 1074246..1075091 - 846 Protein_1072 IS630 family transposase -
LXA46_RS05385 (LXA46_05375) 1075262..1075417 + 156 Protein_1073 diacylglycerol kinase family lipid kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1063491..1084033 20542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14514.67 Da        Isoelectric Point: 9.8086

>T229787 WP_000551587.1 NZ_CP089948:1071545-1071910 [Streptococcus pneumoniae TIGR4]
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK

Download         Length: 366 bp

>T229787 NZ_CP124517:2595740-2596204 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10751.45 Da        Isoelectric Point: 5.1991

>AT229787 WP_000794247.1 NZ_CP089948:1071900-1072193 [Streptococcus pneumoniae TIGR4]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV

Download         Length: 294 bp

>AT229787 NZ_CP124517:2595405-2595740 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6AF3
PDB 6AF4

Antitoxin

Source ID Structure
PDB 6AF3
PDB 6AF4
AlphaFold DB A0A0H2UQ20

References