Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-couple_hipB |
Location | 1071545..1072193 | Replicon | chromosome |
Accession | NZ_CP089948 | ||
Organism | Streptococcus pneumoniae TIGR4 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0H2UQ08 |
Locus tag | LXA46_RS05355 | Protein ID | WP_000551587.1 |
Coordinates | 1071545..1071910 (+) | Length | 122 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0H2UQ20 |
Locus tag | LXA46_RS05360 | Protein ID | WP_000794247.1 |
Coordinates | 1071900..1072193 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LXA46_RS05315 (LXA46_05305) | 1066784..1067401 | + | 618 | WP_000424676.1 | Rha family transcriptional regulator | - |
LXA46_RS05320 (LXA46_05310) | 1067436..1067888 | + | 453 | WP_000141102.1 | hypothetical protein | - |
LXA46_RS05325 (LXA46_05315) | 1067885..1068331 | + | 447 | WP_000171242.1 | DnaD domain protein | - |
LXA46_RS05330 (LXA46_05320) | 1068343..1069227 | + | 885 | WP_000838905.1 | ATP-binding protein | - |
LXA46_RS05335 (LXA46_05325) | 1069476..1070126 | + | 651 | WP_000138311.1 | hypothetical protein | - |
LXA46_RS05340 (LXA46_05330) | 1070173..1070601 | + | 429 | WP_000918210.1 | hypothetical protein | - |
LXA46_RS05345 (LXA46_05335) | 1070609..1070920 | + | 312 | WP_001113833.1 | hypothetical protein | - |
LXA46_RS05350 (LXA46_05340) | 1070938..1071348 | + | 411 | WP_000162610.1 | hypothetical protein | - |
LXA46_RS05355 (LXA46_05345) | 1071545..1071910 | + | 366 | WP_000551587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LXA46_RS05360 (LXA46_05350) | 1071900..1072193 | + | 294 | WP_000794247.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LXA46_RS05365 (LXA46_05355) | 1072211..1073401 | + | 1191 | WP_000123149.1 | hypothetical protein | - |
LXA46_RS05370 (LXA46_05360) | 1073404..1073580 | + | 177 | WP_000346914.1 | hypothetical protein | - |
LXA46_RS05375 (LXA46_05365) | 1073900..1074346 | - | 447 | WP_061631657.1 | tyrosine-type recombinase/integrase | - |
LXA46_RS05380 (LXA46_05370) | 1074246..1075091 | - | 846 | Protein_1072 | IS630 family transposase | - |
LXA46_RS05385 (LXA46_05375) | 1075262..1075417 | + | 156 | Protein_1073 | diacylglycerol kinase family lipid kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1063491..1084033 | 20542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 122 a.a. Molecular weight: 14514.67 Da Isoelectric Point: 9.8086
>T229787 WP_000551587.1 NZ_CP089948:1071545-1071910 [Streptococcus pneumoniae TIGR4]
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK
Download Length: 366 bp
>T229787 NZ_CP124517:2595740-2596204 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10751.45 Da Isoelectric Point: 5.1991
>AT229787 WP_000794247.1 NZ_CP089948:1071900-1072193 [Streptococcus pneumoniae TIGR4]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV
Download Length: 294 bp
>AT229787 NZ_CP124517:2595405-2595740 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6AF3 | |
PDB | 6AF4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H2UQ20 |