Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-couple_hipB |
Location | 1071285..1071933 | Replicon | chromosome |
Accession | NC_003028 | ||
Organism | Streptococcus pneumoniae TIGR4 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0H2UQ08 |
Locus tag | SP_RS05655 | Protein ID | WP_000551587.1 |
Coordinates | 1071285..1071650 (+) | Length | 122 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0H2UQ20 |
Locus tag | SP_RS05660 | Protein ID | WP_000794247.1 |
Coordinates | 1071640..1071933 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SP_RS05615 (SP_1134) | 1066524..1067141 | + | 618 | WP_000424676.1 | Rha family transcriptional regulator | - |
SP_RS05620 (SP_1135) | 1067176..1067628 | + | 453 | WP_000141102.1 | hypothetical protein | - |
SP_RS05625 (SP_1136) | 1067625..1068071 | + | 447 | WP_000171242.1 | DnaD domain protein | - |
SP_RS05630 (SP_1137) | 1068083..1068967 | + | 885 | WP_000838905.1 | ATP-binding protein | - |
SP_RS05635 (SP_1139) | 1069216..1069866 | + | 651 | WP_000138311.1 | hypothetical protein | - |
SP_RS05640 (SP_1140) | 1069913..1070341 | + | 429 | WP_000918210.1 | hypothetical protein | - |
SP_RS05645 (SP_1141) | 1070349..1070660 | + | 312 | WP_001113833.1 | hypothetical protein | - |
SP_RS05650 (SP_1142) | 1070678..1071088 | + | 411 | WP_000162610.1 | hypothetical protein | - |
SP_RS05655 (SP_1143) | 1071285..1071650 | + | 366 | WP_000551587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
SP_RS05660 (SP_1144) | 1071640..1071933 | + | 294 | WP_000794247.1 | helix-turn-helix transcriptional regulator | Antitoxin |
SP_RS05665 (SP_1145) | 1071951..1073141 | + | 1191 | WP_000123149.1 | hypothetical protein | - |
SP_RS13035 (SP_1146) | 1073144..1073320 | + | 177 | WP_000346914.1 | hypothetical protein | - |
SP_RS12125 | 1073640..1074086 | - | 447 | WP_061631657.1 | tyrosine-type recombinase/integrase | - |
SP_RS12130 | 1073986..1074831 | - | 846 | Protein_1067 | IS630 family transposase | - |
SP_RS12795 | 1075002..1075157 | + | 156 | Protein_1068 | diacylglycerol kinase family lipid kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1063231..1083773 | 20542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 122 a.a. Molecular weight: 14514.67 Da Isoelectric Point: 9.8086
>T20635 WP_000551587.1 NC_003028:1071285-1071650 [Streptococcus pneumoniae TIGR4]
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK
Download Length: 366 bp
>T20635 NC_003028:1071285-1071650 [Streptococcus pneumoniae TIGR4]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGCAATGAGCCTGTTTTTGATTATATGCGAGAGCTTACCAGTAAAAA
AGGGAAAGATAGCAGAATTAAGCTTAATAAAATTAATGATTATATTGAGTTGTTAAGCCAACATGGAACACGCGCAGGCG
AACCATATATTAAGCATTTAGATGCTGAAATTTGGGAGCTGAGACCACTTAGAGATAGAATTTTATTTGTTGCTTGGATG
GATGGTAGTTTTGTTTTACTGCATCATTTTATGAAAAGGACACAGAAAACACCCAAAAGAGAGATTGAGCAAGCTAAACG
TGAACTTGCAGATTTAAAAGAAAGAGGTTTAGACAATGAAAAATAA
GTGCATAATATCTATTTTTACAAGGATAAAAACGGCAATGAGCCTGTTTTTGATTATATGCGAGAGCTTACCAGTAAAAA
AGGGAAAGATAGCAGAATTAAGCTTAATAAAATTAATGATTATATTGAGTTGTTAAGCCAACATGGAACACGCGCAGGCG
AACCATATATTAAGCATTTAGATGCTGAAATTTGGGAGCTGAGACCACTTAGAGATAGAATTTTATTTGTTGCTTGGATG
GATGGTAGTTTTGTTTTACTGCATCATTTTATGAAAAGGACACAGAAAACACCCAAAAGAGAGATTGAGCAAGCTAAACG
TGAACTTGCAGATTTAAAAGAAAGAGGTTTAGACAATGAAAAATAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10751.45 Da Isoelectric Point: 5.1991
>AT20635 WP_000794247.1 NC_003028:1071640-1071933 [Streptococcus pneumoniae TIGR4]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV
Download Length: 294 bp
>AT20635 NC_003028:1071640-1071933 [Streptococcus pneumoniae TIGR4]
ATGAAAAATAATGCTATTGGTAGTAACTGGAAAGATGTAAGAGCTGAATTATTCAGCAAAGAGGAAATTTTGGAAAGTGA
TATGCGCGTGGCTATCATGAGTGAGCTTATCGAGGCTAGAAATGAAAAGGGTATTAGTCAGAAGAAACTAGAGGAGATGA
GCGGTGTTAGTCAGCCAGTTATCGCTAGAATGGAAACAGGAAAGACAAGCCCACAACTTGATACAGTATTAAAAGTGTTG
GCAAGTCTTGGTAAGACCTTAGCTGTTGTACCATTAGAGCATGAGCAGGTTTAG
ATGAAAAATAATGCTATTGGTAGTAACTGGAAAGATGTAAGAGCTGAATTATTCAGCAAAGAGGAAATTTTGGAAAGTGA
TATGCGCGTGGCTATCATGAGTGAGCTTATCGAGGCTAGAAATGAAAAGGGTATTAGTCAGAAGAAACTAGAGGAGATGA
GCGGTGTTAGTCAGCCAGTTATCGCTAGAATGGAAACAGGAAAGACAAGCCCACAACTTGATACAGTATTAAAAGTGTTG
GCAAGTCTTGGTAAGACCTTAGCTGTTGTACCATTAGAGCATGAGCAGGTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6AF3 | |
PDB | 6AF4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H2UQ20 |