Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-couple_hipB |
Location | 1071545..1072193 | Replicon | chromosome |
Accession | NZ_CP035239 | ||
Organism | Streptococcus pneumoniae strain TVO_TIGR4 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0H2UQ08 |
Locus tag | EQH41_RS05345 | Protein ID | WP_000551587.1 |
Coordinates | 1071545..1071910 (+) | Length | 122 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0H2UQ20 |
Locus tag | EQH41_RS05350 | Protein ID | WP_000794247.1 |
Coordinates | 1071900..1072193 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EQH41_RS05305 (EQH41_05640) | 1066784..1067401 | + | 618 | WP_000424676.1 | Rha family transcriptional regulator | - |
EQH41_RS05310 (EQH41_05645) | 1067436..1067888 | + | 453 | WP_000141102.1 | hypothetical protein | - |
EQH41_RS05315 (EQH41_05650) | 1067885..1068331 | + | 447 | WP_000171242.1 | DnaD domain protein | - |
EQH41_RS05320 (EQH41_05655) | 1068343..1069227 | + | 885 | WP_000838905.1 | ATP-binding protein | - |
EQH41_RS05325 (EQH41_05660) | 1069476..1070126 | + | 651 | WP_000138311.1 | hypothetical protein | - |
EQH41_RS05330 (EQH41_05665) | 1070173..1070601 | + | 429 | WP_000918210.1 | hypothetical protein | - |
EQH41_RS05335 (EQH41_05670) | 1070609..1070920 | + | 312 | WP_001113833.1 | hypothetical protein | - |
EQH41_RS05340 (EQH41_05675) | 1070938..1071348 | + | 411 | WP_000162610.1 | hypothetical protein | - |
EQH41_RS05345 (EQH41_05680) | 1071545..1071910 | + | 366 | WP_000551587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EQH41_RS05350 (EQH41_05685) | 1071900..1072193 | + | 294 | WP_000794247.1 | helix-turn-helix transcriptional regulator | Antitoxin |
EQH41_RS05355 (EQH41_05690) | 1072211..1073401 | + | 1191 | WP_000123149.1 | hypothetical protein | - |
EQH41_RS05360 | 1073404..1073580 | + | 177 | WP_000346914.1 | hypothetical protein | - |
EQH41_RS05365 (EQH41_05695) | 1073900..1074346 | - | 447 | WP_061631657.1 | tyrosine-type recombinase/integrase | - |
EQH41_RS05370 (EQH41_05700) | 1074246..1075091 | - | 846 | Protein_1071 | IS630 family transposase | - |
EQH41_RS05375 (EQH41_05710) | 1075262..1075417 | + | 156 | Protein_1072 | diacylglycerol kinase family lipid kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1063491..1084033 | 20542 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 122 a.a. Molecular weight: 14514.67 Da Isoelectric Point: 9.8086
>T117442 WP_000551587.1 NZ_CP035239:1071545-1071910 [Streptococcus pneumoniae]
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK
Download Length: 366 bp
>T117442 NZ_CP035239:1071545-1071910 [Streptococcus pneumoniae]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGCAATGAGCCTGTTTTTGATTATATGCGAGAGCTTACCAGTAAAAA
AGGGAAAGATAGCAGAATTAAGCTTAATAAAATTAATGATTATATTGAGTTGTTAAGCCAACATGGAACACGCGCAGGCG
AACCATATATTAAGCATTTAGATGCTGAAATTTGGGAGCTGAGACCACTTAGAGATAGAATTTTATTTGTTGCTTGGATG
GATGGTAGTTTTGTTTTACTGCATCATTTTATGAAAAGGACACAGAAAACACCCAAAAGAGAGATTGAGCAAGCTAAACG
TGAACTTGCAGATTTAAAAGAAAGAGGTTTAGACAATGAAAAATAA
GTGCATAATATCTATTTTTACAAGGATAAAAACGGCAATGAGCCTGTTTTTGATTATATGCGAGAGCTTACCAGTAAAAA
AGGGAAAGATAGCAGAATTAAGCTTAATAAAATTAATGATTATATTGAGTTGTTAAGCCAACATGGAACACGCGCAGGCG
AACCATATATTAAGCATTTAGATGCTGAAATTTGGGAGCTGAGACCACTTAGAGATAGAATTTTATTTGTTGCTTGGATG
GATGGTAGTTTTGTTTTACTGCATCATTTTATGAAAAGGACACAGAAAACACCCAAAAGAGAGATTGAGCAAGCTAAACG
TGAACTTGCAGATTTAAAAGAAAGAGGTTTAGACAATGAAAAATAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10751.45 Da Isoelectric Point: 5.1991
>AT117442 WP_000794247.1 NZ_CP035239:1071900-1072193 [Streptococcus pneumoniae]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV
Download Length: 294 bp
>AT117442 NZ_CP035239:1071900-1072193 [Streptococcus pneumoniae]
ATGAAAAATAATGCTATTGGTAGTAACTGGAAAGATGTAAGAGCTGAATTATTCAGCAAAGAGGAAATTTTGGAAAGTGA
TATGCGCGTGGCTATCATGAGTGAGCTTATCGAGGCTAGAAATGAAAAGGGTATTAGTCAGAAGAAACTAGAGGAGATGA
GCGGTGTTAGTCAGCCAGTTATCGCTAGAATGGAAACAGGAAAGACAAGCCCACAACTTGATACAGTATTAAAAGTGTTG
GCAAGTCTTGGTAAGACCTTAGCTGTTGTACCATTAGAGCATGAGCAGGTTTAG
ATGAAAAATAATGCTATTGGTAGTAACTGGAAAGATGTAAGAGCTGAATTATTCAGCAAAGAGGAAATTTTGGAAAGTGA
TATGCGCGTGGCTATCATGAGTGAGCTTATCGAGGCTAGAAATGAAAAGGGTATTAGTCAGAAGAAACTAGAGGAGATGA
GCGGTGTTAGTCAGCCAGTTATCGCTAGAATGGAAACAGGAAAGACAAGCCCACAACTTGATACAGTATTAAAAGTGTTG
GCAAGTCTTGGTAAGACCTTAGCTGTTGTACCATTAGAGCATGAGCAGGTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 6AF3 | |
PDB | 6AF4 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 6AF3 | |
PDB | 6AF4 | |
AlphaFold DB | A0A0H2UQ20 |