117442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1071545..1072193 Replicon chromosome
Accession NZ_CP035239
Organism Streptococcus pneumoniae strain TVO_TIGR4

Toxin (Protein)


Gene name higB Uniprot ID A0A0H2UQ08
Locus tag EQH41_RS05345 Protein ID WP_000551587.1
Coordinates 1071545..1071910 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0H2UQ20
Locus tag EQH41_RS05350 Protein ID WP_000794247.1
Coordinates 1071900..1072193 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH41_RS05305 (EQH41_05640) 1066784..1067401 + 618 WP_000424676.1 Rha family transcriptional regulator -
EQH41_RS05310 (EQH41_05645) 1067436..1067888 + 453 WP_000141102.1 hypothetical protein -
EQH41_RS05315 (EQH41_05650) 1067885..1068331 + 447 WP_000171242.1 DnaD domain protein -
EQH41_RS05320 (EQH41_05655) 1068343..1069227 + 885 WP_000838905.1 ATP-binding protein -
EQH41_RS05325 (EQH41_05660) 1069476..1070126 + 651 WP_000138311.1 hypothetical protein -
EQH41_RS05330 (EQH41_05665) 1070173..1070601 + 429 WP_000918210.1 hypothetical protein -
EQH41_RS05335 (EQH41_05670) 1070609..1070920 + 312 WP_001113833.1 hypothetical protein -
EQH41_RS05340 (EQH41_05675) 1070938..1071348 + 411 WP_000162610.1 hypothetical protein -
EQH41_RS05345 (EQH41_05680) 1071545..1071910 + 366 WP_000551587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQH41_RS05350 (EQH41_05685) 1071900..1072193 + 294 WP_000794247.1 helix-turn-helix transcriptional regulator Antitoxin
EQH41_RS05355 (EQH41_05690) 1072211..1073401 + 1191 WP_000123149.1 hypothetical protein -
EQH41_RS05360 1073404..1073580 + 177 WP_000346914.1 hypothetical protein -
EQH41_RS05365 (EQH41_05695) 1073900..1074346 - 447 WP_061631657.1 tyrosine-type recombinase/integrase -
EQH41_RS05370 (EQH41_05700) 1074246..1075091 - 846 Protein_1071 IS630 family transposase -
EQH41_RS05375 (EQH41_05710) 1075262..1075417 + 156 Protein_1072 diacylglycerol kinase family lipid kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1063491..1084033 20542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14514.67 Da        Isoelectric Point: 9.8086

>T117442 WP_000551587.1 NZ_CP035239:1071545-1071910 [Streptococcus pneumoniae]
VHNIYFYKDKNGNEPVFDYMRELTSKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWM
DGSFVLLHHFMKRTQKTPKREIEQAKRELADLKERGLDNEK

Download         Length: 366 bp

>T117442 NZ_CP035239:1071545-1071910 [Streptococcus pneumoniae]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGCAATGAGCCTGTTTTTGATTATATGCGAGAGCTTACCAGTAAAAA
AGGGAAAGATAGCAGAATTAAGCTTAATAAAATTAATGATTATATTGAGTTGTTAAGCCAACATGGAACACGCGCAGGCG
AACCATATATTAAGCATTTAGATGCTGAAATTTGGGAGCTGAGACCACTTAGAGATAGAATTTTATTTGTTGCTTGGATG
GATGGTAGTTTTGTTTTACTGCATCATTTTATGAAAAGGACACAGAAAACACCCAAAAGAGAGATTGAGCAAGCTAAACG
TGAACTTGCAGATTTAAAAGAAAGAGGTTTAGACAATGAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10751.45 Da        Isoelectric Point: 5.1991

>AT117442 WP_000794247.1 NZ_CP035239:1071900-1072193 [Streptococcus pneumoniae]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEHEQV

Download         Length: 294 bp

>AT117442 NZ_CP035239:1071900-1072193 [Streptococcus pneumoniae]
ATGAAAAATAATGCTATTGGTAGTAACTGGAAAGATGTAAGAGCTGAATTATTCAGCAAAGAGGAAATTTTGGAAAGTGA
TATGCGCGTGGCTATCATGAGTGAGCTTATCGAGGCTAGAAATGAAAAGGGTATTAGTCAGAAGAAACTAGAGGAGATGA
GCGGTGTTAGTCAGCCAGTTATCGCTAGAATGGAAACAGGAAAGACAAGCCCACAACTTGATACAGTATTAAAAGTGTTG
GCAAGTCTTGGTAAGACCTTAGCTGTTGTACCATTAGAGCATGAGCAGGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6AF3
PDB 6AF4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2UQ20

References