Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-ParD |
Location | 3506198..3507194 | Replicon | chromosome |
Accession | NC_008596 | ||
Organism | Mycobacterium smegmatis str. MC2 155 |
Toxin (Protein)
Gene name | pezT | Uniprot ID | I7FEA2 |
Locus tag | MSMEG_RS16715 | Protein ID | WP_011729066.1 |
Coordinates | 3506616..3507194 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | I7GB97 |
Locus tag | MSMEG_RS16710 | Protein ID | WP_003894879.1 |
Coordinates | 3506198..3506590 (+) | Length | 131 a.a. |
Genomic Context
Location: 3501227..3501832 (606 bp)
Type: Others
Protein ID: WP_011729062.1
Type: Others
Protein ID: WP_011729062.1
Location: 3502304..3503770 (1467 bp)
Type: Others
Protein ID: WP_011726646.1
Type: Others
Protein ID: WP_011726646.1
Location: 3505505..3506134 (630 bp)
Type: Others
Protein ID: WP_011729065.1
Type: Others
Protein ID: WP_011729065.1
Location: 3506198..3506590 (393 bp)
Type: Antitoxin
Protein ID: WP_003894879.1
Type: Antitoxin
Protein ID: WP_003894879.1
Location: 3506616..3507194 (579 bp)
Type: Toxin
Protein ID: WP_011729066.1
Type: Toxin
Protein ID: WP_011729066.1
Location: 3508893..3509048 (156 bp)
Type: Others
Protein ID: WP_003894882.1
Type: Others
Protein ID: WP_003894882.1
Location: 3509243..3510631 (1389 bp)
Type: Others
Protein ID: WP_014877699.1
Type: Others
Protein ID: WP_014877699.1
Location: 3511367..3512173 (807 bp)
Type: Others
Protein ID: WP_011729071.1
Type: Others
Protein ID: WP_011729071.1
Location: 3501834..3502145 (312 bp)
Type: Others
Protein ID: Protein_3314
Type: Others
Protein ID: Protein_3314
Location: 3503726..3505195 (1470 bp)
Type: Others
Protein ID: WP_011729064.1
Type: Others
Protein ID: WP_011729064.1
Location: 3507206..3508558 (1353 bp)
Type: Others
Protein ID: WP_011729067.1
Type: Others
Protein ID: WP_011729067.1
Location: 3510665..3511207 (543 bp)
Type: Others
Protein ID: WP_014877700.1
Type: Others
Protein ID: WP_014877700.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MSMEG_RS16685 (MSMEG_3430) | 3501227..3501832 | + | 606 | WP_011729062.1 | class I SAM-dependent methyltransferase | - |
MSMEG_RS16690 (MSMEG_3431) | 3501834..3502145 | - | 312 | Protein_3314 | GMC family oxidoreductase | - |
MSMEG_RS16695 (MSMEG_3433) | 3502304..3503770 | + | 1467 | WP_011726646.1 | IS1634-like element IS1549 family transposase | - |
MSMEG_RS16700 (MSMEG_3432) | 3503726..3505195 | - | 1470 | WP_011729064.1 | choline dehydrogenase | - |
MSMEG_RS16705 (MSMEG_3434) | 3505505..3506134 | + | 630 | WP_011729065.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
MSMEG_RS16710 (MSMEG_3435) | 3506198..3506590 | + | 393 | WP_003894879.1 | hypothetical protein | Antitoxin |
MSMEG_RS16715 (MSMEG_3436) | 3506616..3507194 | + | 579 | WP_011729066.1 | zeta toxin family protein | Toxin |
MSMEG_RS16720 (MSMEG_3437) | 3507206..3508558 | - | 1353 | WP_011729067.1 | LysM peptidoglycan-binding domain-containing protein | - |
MSMEG_RS33555 (MSMEG_3439) | 3508893..3509048 | + | 156 | WP_003894882.1 | hypothetical protein | - |
MSMEG_RS16725 (MSMEG_3440) | 3509243..3510631 | + | 1389 | WP_014877699.1 | L-serine ammonia-lyase | - |
MSMEG_RS16730 (MSMEG_3441) | 3510665..3511207 | - | 543 | WP_014877700.1 | hypothetical protein | - |
MSMEG_RS16735 (MSMEG_3442) | 3511367..3512173 | + | 807 | WP_011729071.1 | transporter substrate-binding domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 3502259..3503770 | 1511 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21132.34 Da Isoelectric Point: 9.9425
>T21787 WP_011729066.1 NC_008596:3506616-3507194 [Mycolicibacterium smegmatis MC2 155]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE
Download Length: 579 bp
>T21787 NC_008596:3506616-3507194 [Mycolicibacterium smegmatis MC2 155]
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG
Antitoxin
Download Length: 131 a.a. Molecular weight: 13841.29 Da Isoelectric Point: 4.9246
>AT21787 WP_003894879.1 NC_008596:3506198-3506590 [Mycolicibacterium smegmatis MC2 155]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR
Download Length: 393 bp
>AT21787 NC_008596:3506198-3506590 [Mycolicibacterium smegmatis MC2 155]
ATGACTGAGACCGCAGATCGGGTCACTCGCTTCGCCGCAGACCTGGTGGAGAGCGCCGCGGCCGAAGGCGCACGTCAGAG
TAGGTCGGCCAAGCAGCAACTCGACCATTGGGCACGAGTGGGGCGGGCGGTGTCGAGCCAACACACCGCCGCCCGCCGCC
GGGTGGAAGCCGCGCTCGCCGGGGACCTGGCGCTACGCGATCTGACTCCTGAGGAAGGCGTCGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAGAATCTGGCGCACACCGATTACGGCCAGGTCCTCGCCGGGCGCGGCGTGACCACCGTCGCTCT
CGACGACGACGGTGCCATCGTGCGGTACCAACCGGACGGCACCACGACCGTGCTGGCTCCTGCGCAGCGGTGA
ATGACTGAGACCGCAGATCGGGTCACTCGCTTCGCCGCAGACCTGGTGGAGAGCGCCGCGGCCGAAGGCGCACGTCAGAG
TAGGTCGGCCAAGCAGCAACTCGACCATTGGGCACGAGTGGGGCGGGCGGTGTCGAGCCAACACACCGCCGCCCGCCGCC
GGGTGGAAGCCGCGCTCGCCGGGGACCTGGCGCTACGCGATCTGACTCCTGAGGAAGGCGTCGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAGAATCTGGCGCACACCGATTACGGCCAGGTCCTCGCCGGGCGCGGCGTGACCACCGTCGCTCT
CGACGACGACGGTGCCATCGTGCGGTACCAACCGGACGGCACCACGACCGTGCTGGCTCCTGCGCAGCGGTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A653FN11 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2U9PRP8 |