21787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3506198..3507194 Replicon chromosome
Accession NC_008596
Organism Mycobacterium smegmatis str. MC2 155

Toxin (Protein)


Gene name pezT Uniprot ID I7FEA2
Locus tag MSMEG_RS16715 Protein ID WP_011729066.1
Coordinates 3506616..3507194 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag MSMEG_RS16710 Protein ID WP_003894879.1
Coordinates 3506198..3506590 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSMEG_RS16685 (MSMEG_3430) 3501227..3501832 + 606 WP_011729062.1 class I SAM-dependent methyltransferase -
MSMEG_RS16690 (MSMEG_3431) 3501834..3502145 - 312 Protein_3314 GMC family oxidoreductase -
MSMEG_RS16695 (MSMEG_3433) 3502304..3503770 + 1467 WP_011726646.1 IS1634-like element IS1549 family transposase -
MSMEG_RS16700 (MSMEG_3432) 3503726..3505195 - 1470 WP_011729064.1 choline dehydrogenase -
MSMEG_RS16705 (MSMEG_3434) 3505505..3506134 + 630 WP_011729065.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
MSMEG_RS16710 (MSMEG_3435) 3506198..3506590 + 393 WP_003894879.1 hypothetical protein Antitoxin
MSMEG_RS16715 (MSMEG_3436) 3506616..3507194 + 579 WP_011729066.1 zeta toxin family protein Toxin
MSMEG_RS16720 (MSMEG_3437) 3507206..3508558 - 1353 WP_011729067.1 LysM peptidoglycan-binding domain-containing protein -
MSMEG_RS33555 (MSMEG_3439) 3508893..3509048 + 156 WP_003894882.1 hypothetical protein -
MSMEG_RS16725 (MSMEG_3440) 3509243..3510631 + 1389 WP_014877699.1 L-serine ammonia-lyase -
MSMEG_RS16730 (MSMEG_3441) 3510665..3511207 - 543 WP_014877700.1 hypothetical protein -
MSMEG_RS16735 (MSMEG_3442) 3511367..3512173 + 807 WP_011729071.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3502259..3503770 1511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21132.34 Da        Isoelectric Point: 9.9425

>T21787 WP_011729066.1 NC_008596:3506616-3507194 [Mycolicibacterium smegmatis MC2 155]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

>T21787 NC_008596:3506616-3507194 [Mycolicibacterium smegmatis MC2 155]
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT21787 WP_003894879.1 NC_008596:3506198-3506590 [Mycolicibacterium smegmatis MC2 155]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp

>AT21787 NC_008596:3506198-3506590 [Mycolicibacterium smegmatis MC2 155]
ATGACTGAGACCGCAGATCGGGTCACTCGCTTCGCCGCAGACCTGGTGGAGAGCGCCGCGGCCGAAGGCGCACGTCAGAG
TAGGTCGGCCAAGCAGCAACTCGACCATTGGGCACGAGTGGGGCGGGCGGTGTCGAGCCAACACACCGCCGCCCGCCGCC
GGGTGGAAGCCGCGCTCGCCGGGGACCTGGCGCTACGCGATCTGACTCCTGAGGAAGGCGTCGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAGAATCTGGCGCACACCGATTACGGCCAGGTCCTCGCCGGGCGCGGCGTGACCACCGTCGCTCT
CGACGACGACGGTGCCATCGTGCGGTACCAACCGGACGGCACCACGACCGTGCTGGCTCCTGCGCAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653FN11

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PRP8

References