Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3506198..3507194 Replicon chromosome
Accession NC_008596
Organism Mycobacterium smegmatis str. MC2 155

Toxin (Protein)


Gene name pezT Uniprot ID I7FEA2
Locus tag MSMEG_RS16715 Protein ID WP_011729066.1
Coordinates 3506616..3507194 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag MSMEG_RS16710 Protein ID WP_003894879.1
Coordinates 3506198..3506590 (+) Length 131 a.a.

Genomic Context


MSMEG_RS16685MSMEG_RS16695MSMEG_RS16705MSMEG_RS16710MSMEG_RS16715MSMEG_RS33555MSMEG_RS16725MSMEG_RS16735MSMEG_RS16690MSMEG_RS16700MSMEG_RS16720MSMEG_RS16730
Location: 3501227..3501832 (606 bp)
Type: Others
Protein ID: WP_011729062.1
Location: 3502304..3503770 (1467 bp)
Type: Others
Protein ID: WP_011726646.1
Location: 3505505..3506134 (630 bp)
Type: Others
Protein ID: WP_011729065.1
Location: 3506198..3506590 (393 bp)
Type: Antitoxin
Protein ID: WP_003894879.1
Location: 3506616..3507194 (579 bp)
Type: Toxin
Protein ID: WP_011729066.1
Location: 3508893..3509048 (156 bp)
Type: Others
Protein ID: WP_003894882.1
Location: 3509243..3510631 (1389 bp)
Type: Others
Protein ID: WP_014877699.1
Location: 3511367..3512173 (807 bp)
Type: Others
Protein ID: WP_011729071.1
Location: 3501834..3502145 (312 bp)
Type: Others
Protein ID: Protein_3314
Location: 3503726..3505195 (1470 bp)
Type: Others
Protein ID: WP_011729064.1
Location: 3507206..3508558 (1353 bp)
Type: Others
Protein ID: WP_011729067.1
Location: 3510665..3511207 (543 bp)
Type: Others
Protein ID: WP_014877700.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MSMEG_RS16685 (MSMEG_3430)3501227..3501832+606WP_011729062.1class I SAM-dependent methyltransferase-
MSMEG_RS16690 (MSMEG_3431)3501834..3502145-312Protein_3314GMC family oxidoreductase-
MSMEG_RS16695 (MSMEG_3433)3502304..3503770+1467WP_011726646.1IS1634-like element IS1549 family transposase-
MSMEG_RS16700 (MSMEG_3432)3503726..3505195-1470WP_011729064.1choline dehydrogenase-
MSMEG_RS16705 (MSMEG_3434)3505505..3506134+630WP_011729065.1FKBP-type peptidyl-prolyl cis-trans isomerase-
MSMEG_RS16710 (MSMEG_3435)3506198..3506590+393WP_003894879.1hypothetical proteinAntitoxin
MSMEG_RS16715 (MSMEG_3436)3506616..3507194+579WP_011729066.1zeta toxin family proteinToxin
MSMEG_RS16720 (MSMEG_3437)3507206..3508558-1353WP_011729067.1LysM peptidoglycan-binding domain-containing protein-
MSMEG_RS33555 (MSMEG_3439)3508893..3509048+156WP_003894882.1hypothetical protein-
MSMEG_RS16725 (MSMEG_3440)3509243..3510631+1389WP_014877699.1L-serine ammonia-lyase-
MSMEG_RS16730 (MSMEG_3441)3510665..3511207-543WP_014877700.1hypothetical protein-
MSMEG_RS16735 (MSMEG_3442)3511367..3512173+807WP_011729071.1transporter substrate-binding domain-containing protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--3502259..35037701511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21132.34 Da        Isoelectric Point: 9.9425

>T21787 WP_011729066.1 NC_008596:3506616-3507194 [Mycolicibacterium smegmatis MC2 155]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

>T21787 NC_008596:3506616-3507194 [Mycolicibacterium smegmatis MC2 155]
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT21787 WP_003894879.1 NC_008596:3506198-3506590 [Mycolicibacterium smegmatis MC2 155]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp

>AT21787 NC_008596:3506198-3506590 [Mycolicibacterium smegmatis MC2 155]
ATGACTGAGACCGCAGATCGGGTCACTCGCTTCGCCGCAGACCTGGTGGAGAGCGCCGCGGCCGAAGGCGCACGTCAGAG
TAGGTCGGCCAAGCAGCAACTCGACCATTGGGCACGAGTGGGGCGGGCGGTGTCGAGCCAACACACCGCCGCCCGCCGCC
GGGTGGAAGCCGCGCTCGCCGGGGACCTGGCGCTACGCGATCTGACTCCTGAGGAAGGCGTCGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAGAATCTGGCGCACACCGATTACGGCCAGGTCCTCGCCGGGCGCGGCGTGACCACCGTCGCTCT
CGACGACGACGGTGCCATCGTGCGGTACCAACCGGACGGCACCACGACCGTGCTGGCTCCTGCGCAGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A653FN11


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2U9PRP8

References