Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3507811..3508807 Replicon chromosome
Accession NC_018289
Organism Mycobacterium smegmatis str. MC2 155

Toxin (Protein)


Gene name pezT Uniprot ID I7FEA2
Locus tag MSMEI_RS16930 Protein ID WP_011729066.1
Coordinates 3508229..3508807 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag MSMEI_RS16925 Protein ID WP_003894879.1
Coordinates 3507811..3508203 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSMEI_RS16900 3502840..3503445 + 606 WP_011729062.1 class I SAM-dependent methyltransferase -
MSMEI_RS16905 3503447..3503758 - 312 Protein_3312 GMC family oxidoreductase -
MSMEI_RS16910 3503917..3505383 + 1467 WP_011726646.1 IS1634-like element IS1549 family transposase -
MSMEI_RS16915 3505339..3506808 - 1470 WP_011729064.1 choline dehydrogenase -
MSMEI_RS16920 3507118..3507747 + 630 WP_011729065.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
MSMEI_RS16925 3507811..3508203 + 393 WP_003894879.1 hypothetical protein Antitoxin
MSMEI_RS16930 3508229..3508807 + 579 WP_011729066.1 zeta toxin family protein Toxin
MSMEI_RS16935 3508819..3510171 - 1353 WP_011729067.1 LysM peptidoglycan-binding domain-containing protein -
MSMEI_RS35450 3510506..3510661 + 156 WP_003894882.1 hypothetical protein -
MSMEI_RS16945 3510856..3512244 + 1389 WP_014877699.1 L-serine ammonia-lyase -
MSMEI_RS16950 3512278..3512820 - 543 WP_014877700.1 hypothetical protein -
MSMEI_RS16955 3512980..3513786 + 807 WP_011729071.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3503872..3505383 1511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21132.34 Da        Isoelectric Point: 9.9425

>T28142 WP_011729066.1 NC_018289:3508229-3508807 [Mycolicibacterium smegmatis MC2 155]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

>T28142 NC_018289:3508229-3508807 [Mycolicibacterium smegmatis MC2 155]
GTGAAACGACTCGATCTCGTCGTTGGTCCCAACGGCGCGGGCAAGAGCACTTTCGTCGAACTCACATTGGCCCCGCTGCT
GACGGGCAGTGCGTTCGTCAACGCCGACGAGATCGCCAAGCGTCGCTGGCCGCACGCCCCGGCCGAGCACTCCTACGAGG
CCGCACGCATCGCCTCCGACACCCGACTCAAGCTGATCGAACTCGGTGAATCGTTCATCGCCGAAACGGTGTTCTCACAT
CCCTCGAAACTTCAGCTCATCGACACCGCGCAGGCGGCTGGATACACCGTGGTAATGCACGTGGTGATGATCCCCGAGGA
TCTCGCCGTCCTACGCGTGCAGCACCGGGTACGAGCCGGTGGTCACCATGTGCCCGAGGAGAAGATCCGCGAACGGCACC
AACGACTCTGGCCCCTCGTCGCGCTGGCGGCCGCCCGCGCCGACATCTCGACGTTCTATGACAACAGCGCCGTCAGGGGT
CCGCGCATCGTTGCCCAACTCGCCGGCGGATTTGCTGTGGGCCGGCCCGCCTGGCCAATGTGGGCACCCCAGGTGCTCAC
CTCGCGGTGGCCCGAATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT28142 WP_003894879.1 NC_018289:3507811-3508203 [Mycolicibacterium smegmatis MC2 155]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp

>AT28142 NC_018289:3507811-3508203 [Mycolicibacterium smegmatis MC2 155]
ATGACTGAGACCGCAGATCGGGTCACTCGCTTCGCCGCAGACCTGGTGGAGAGCGCCGCGGCCGAAGGCGCACGTCAGAG
TAGGTCGGCCAAGCAGCAACTCGACCATTGGGCACGAGTGGGGCGGGCGGTGTCGAGCCAACACACCGCCGCCCGCCGCC
GGGTGGAAGCCGCGCTCGCCGGGGACCTGGCGCTACGCGATCTGACTCCTGAGGAAGGCGTCGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAGAATCTGGCGCACACCGATTACGGCCAGGTCCTCGCCGGGCGCGGCGTGACCACCGTCGCTCT
CGACGACGACGGTGCCATCGTGCGGTACCAACCGGACGGCACCACGACCGTGCTGGCTCCTGCGCAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653FN11

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PRP8

References