211566

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3437748..3438744 Replicon chromosome
Accession NZ_CP080274
Organism Mycolicibacterium smegmatis strain Jucho

Toxin (Protein)


Gene name pezT Uniprot ID I7FEA2
Locus tag KZ780_RS16435 Protein ID WP_011729066.1
Coordinates 3438166..3438744 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag KZ780_RS16430 Protein ID WP_003894879.1
Coordinates 3437748..3438140 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ780_RS16405 (KZ780_16285) 3432777..3433382 + 606 WP_011729062.1 class I SAM-dependent methyltransferase -
KZ780_RS16410 (KZ780_16290) 3433384..3433695 - 312 Protein_3259 GMC oxidoreductase -
KZ780_RS16415 (KZ780_16295) 3433854..3435320 + 1467 WP_011726646.1 IS1634-like element IS1549 family transposase -
KZ780_RS16420 (KZ780_16300) 3435276..3436745 - 1470 WP_011729064.1 GMC family oxidoreductase N-terminal domain-containing protein -
KZ780_RS16425 (KZ780_16305) 3437055..3437684 + 630 WP_011729065.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
KZ780_RS16430 (KZ780_16310) 3437748..3438140 + 393 WP_003894879.1 ParD-like family protein Antitoxin
KZ780_RS16435 (KZ780_16315) 3438166..3438744 + 579 WP_011729066.1 zeta toxin family protein Toxin
KZ780_RS16440 (KZ780_16320) 3438756..3440108 - 1353 WP_011729067.1 alpha/beta hydrolase-fold protein -
KZ780_RS16445 (KZ780_16325) 3440443..3440598 + 156 WP_003894882.1 hypothetical protein -
KZ780_RS16450 (KZ780_16330) 3440793..3442181 + 1389 WP_014877699.1 L-serine ammonia-lyase -
KZ780_RS16455 (KZ780_16335) 3442215..3442757 - 543 WP_014877700.1 hypothetical protein -
KZ780_RS16460 (KZ780_16340) 3442917..3443723 + 807 WP_011729071.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3433809..3435320 1511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21132.34 Da        Isoelectric Point: 9.9425

>T211566 WP_011729066.1 NZ_CP080274:3438166-3438744 [Mycolicibacterium smegmatis]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

>T211566 NZ_CP104966:2794041-2794349 [Phyllobacterium sp. A18/5-2]
TTGAATTATTCAATTGAAAAGACAGATACATTTTTAAACTGGATTGAGGGTTTGCAGGATCTGCGAGCGCGGGCAAGAAT
AATGTCGCGGCTGGACCGGCTGGCTGATGGAAATTTCGGCGATTACAAACTTCTTGGTGAGGATGTCGGAGAGATGCGCA
TTGATTGCGGACCAGGTTATCGGCTCTACTTCACCAAGCAAGGTGGCATTTTGATTATTCTGTTATGCGGTGGCGACAAG
AGCACGCAGAGCAGGGACATTAGAAAAGCGAAGGCAATGGCGCGTGATTTGAAGGAGATACGATCTTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT211566 WP_003894879.1 NZ_CP080274:3437748-3438140 [Mycolicibacterium smegmatis]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp

>AT211566 NZ_CP104966:2794397-2794651 [Phyllobacterium sp. A18/5-2]
ATGATCGAGGAATATTTGCTGGCGGTCTGCGAAGACGGGACATCTTCAGAGATCGCGCGTGCGTTGGGGGCAATAGCTCG
TGCAAGAGGCATTACCGAGCTTGCCCACAAGACCGGTCTCACACGTCAGGCGCTCTACAAAGCCTTGAGCGGTGAGGGCA
ATCCGGAACTTGCGACGATTACTAAAGTCGCCGAAGCGCTTGGCCTCCGATTGACTTTGGTGCGTGCACCGAAAAACAAG
CAAGACGCCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653FN11

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PRP8

References