253442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3517122..3518118 Replicon chromosome
Accession NZ_CP102343
Organism Mycolicibacterium smegmatis strain LM13

Toxin (Protein)


Gene name pezT Uniprot ID I7FEA2
Locus tag NQ426_RS16820 Protein ID WP_011729066.1
Coordinates 3517540..3518118 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag NQ426_RS16815 Protein ID WP_003894879.1
Coordinates 3517122..3517514 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ426_RS16790 (NQ426_16790) 3512151..3512756 + 606 WP_011729062.1 class I SAM-dependent methyltransferase -
NQ426_RS16795 (NQ426_16795) 3512758..3513069 - 312 Protein_3339 GMC oxidoreductase -
NQ426_RS16800 (NQ426_16800) 3513228..3514694 + 1467 WP_011726646.1 IS1634-like element IS1549 family transposase -
NQ426_RS16805 (NQ426_16805) 3514650..3516119 - 1470 WP_011729064.1 GMC family oxidoreductase N-terminal domain-containing protein -
NQ426_RS16810 (NQ426_16810) 3516429..3517058 + 630 WP_011729065.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
NQ426_RS16815 (NQ426_16815) 3517122..3517514 + 393 WP_003894879.1 ParD-like family protein Antitoxin
NQ426_RS16820 (NQ426_16820) 3517540..3518118 + 579 WP_011729066.1 zeta toxin family protein Toxin
NQ426_RS16825 (NQ426_16825) 3518130..3519482 - 1353 WP_011729067.1 alpha/beta hydrolase-fold protein -
NQ426_RS16830 (NQ426_16830) 3519817..3519972 + 156 WP_003894882.1 hypothetical protein -
NQ426_RS16835 (NQ426_16835) 3520167..3521555 + 1389 WP_014877699.1 L-serine ammonia-lyase -
NQ426_RS16840 (NQ426_16840) 3521589..3522095 - 507 WP_011729070.1 hypothetical protein -
NQ426_RS16845 (NQ426_16845) 3522291..3523097 + 807 WP_011729071.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3513183..3514694 1511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21132.34 Da        Isoelectric Point: 9.9425

>T253442 WP_011729066.1 NZ_CP102343:3517540-3518118 [Mycolicibacterium smegmatis]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYEAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT253442 WP_003894879.1 NZ_CP102343:3517122-3517514 [Mycolicibacterium smegmatis]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653FN11

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PRP8

References