211502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15516..15780 Replicon plasmid pSJC33-3
Accession NZ_CP080258
Organism Escherichia coli strain SJC33

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag KZ313_RS24445 Protein ID WP_001331364.1
Coordinates 15628..15780 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 15516..15578 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ313_RS24430 (10755) 10755..13046 - 2292 WP_001289276.1 F-type conjugative transfer protein TrbC -
KZ313_RS24435 (13039) 13039..14109 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
KZ313_RS24440 (14128) 14128..15336 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- (15516) 15516..15578 - 63 NuclAT_0 - Antitoxin
- (15516) 15516..15578 - 63 NuclAT_0 - Antitoxin
- (15516) 15516..15578 - 63 NuclAT_0 - Antitoxin
- (15516) 15516..15578 - 63 NuclAT_0 - Antitoxin
KZ313_RS24445 (15628) 15628..15780 + 153 WP_001331364.1 Hok/Gef family protein Toxin
KZ313_RS24450 (15852) 15852..16103 - 252 WP_001291964.1 hypothetical protein -
KZ313_RS25560 (16465) 16465..16697 + 233 Protein_19 hypothetical protein -
KZ313_RS24455 (16762) 16762..16938 - 177 WP_001054897.1 hypothetical protein -
KZ313_RS24460 (17330) 17330..17539 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
KZ313_RS24465 (17611) 17611..18261 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
KZ313_RS24470 (18335) 18335..20503 - 2169 WP_000698357.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid blaCMY-2 - 1..98807 98807


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T211502 WP_001331364.1 NZ_CP080258:15628-15780 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T211502 NZ_CP104882:c1521804-1521553 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 63 bp

>AT211502 NZ_CP080258:c15578-15516 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References