21021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5086812..5087447 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name hicA Uniprot ID Q7MZD9
Locus tag PLU_RS21495 Protein ID WP_041381194.1
Coordinates 5086812..5086988 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6L9JPT3
Locus tag PLU_RS21500 Protein ID WP_041380398.1
Coordinates 5087040..5087447 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS21485 (plu4351) 5084097..5085035 - 939 WP_011148441.1 pseudouridine-5'-phosphate glycosidase -
PLU_RS21490 (plu4352) 5085038..5086123 - 1086 WP_011148442.1 winged helix-turn-helix transcriptional regulator -
PLU_RS21495 (plu4353) 5086812..5086988 + 177 WP_041381194.1 type II toxin-antitoxin system HicA family toxin Toxin
PLU_RS21500 (plu4354) 5087040..5087447 + 408 WP_041380398.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PLU_RS21505 (plu4355) 5087519..5087773 - 255 WP_011148445.1 cloacin immunity family protein -
PLU_RS21510 (plu4356) 5087822..5088835 - 1014 WP_011148446.1 IS630-like element ISPlu10 family transposase -
PLU_RS21515 (plu4357) 5089228..5090427 - 1200 WP_011148447.1 aspartate/tyrosine/aromatic aminotransferase -
PLU_RS21520 (plu4358) 5090477..5091556 - 1080 WP_011148448.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 5087822..5088835 1013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.95 Da        Isoelectric Point: 11.2826

>T21021 WP_041381194.1 NC_005126:5086812-5086988 [Photorhabdus laumondii subsp. laumondii TTO1]
VKQSEFRRWLKAQGAEFKDGTNHLKVFLNGKQTTMPRHPSKEIPEPLRKLILKQPGIK

Download         Length: 177 bp

>T21021 NC_005126:5086812-5086988 [Photorhabdus laumondii subsp. laumondii TTO1]
GTGAAGCAAAGCGAGTTTCGCCGGTGGCTTAAAGCTCAGGGAGCAGAATTCAAAGATGGGACTAACCACTTGAAAGTTTT
CCTGAACGGTAAGCAAACCACGATGCCAAGGCACCCTAGTAAAGAAATCCCAGAACCACTGAGGAAATTAATATTAAAAC
AGCCAGGCATCAAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14926.07 Da        Isoelectric Point: 4.7620

>AT21021 WP_041380398.1 NC_005126:5087040-5087447 [Photorhabdus laumondii subsp. laumondii TTO1]
MRYPVKFEHDETGWAVMFPDIPEALTGGDTREEALAMAQDALVTAFDFYFEDRREIPTPSTKGEAFVEVPASIAAKVLLL
NTMLQTRTSNAELARLLGTRPQEIQRIVSLSHSTKIDTIANALNALGKHLELVAI

Download         Length: 408 bp

>AT21021 NC_005126:5087040-5087447 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCGATATCCAGTAAAATTCGAACATGACGAAACAGGTTGGGCTGTGATGTTCCCAGATATCCCAGAAGCCTTAACAGG
CGGAGATACCAGAGAAGAAGCATTAGCTATGGCGCAGGATGCTCTGGTTACTGCGTTTGATTTCTACTTTGAAGACCGGC
GCGAAATACCAACACCATCGACTAAAGGTGAAGCTTTTGTCGAAGTACCAGCCAGTATAGCGGCTAAGGTTTTACTGTTG
AATACGATGCTTCAAACAAGAACAAGCAACGCAGAACTTGCACGGTTACTGGGAACTCGACCGCAAGAAATTCAACGTAT
AGTGTCATTAAGTCATAGCACTAAAATTGACACTATCGCGAATGCGTTAAATGCCTTGGGTAAACATCTGGAACTTGTTG
CCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JPT8

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JPT3

References