Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4903544..4904179 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name hicA Uniprot ID Q7MZD9
Locus tag PluDJC_RS21610 Protein ID WP_041381194.1
Coordinates 4903544..4903720 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6L9JPT3
Locus tag PluDJC_RS21615 Protein ID WP_041380398.1
Coordinates 4903772..4904179 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS21600 4900829..4901767 - 939 WP_011148441.1 pseudouridine-5'-phosphate glycosidase -
PluDJC_RS21605 4901770..4902855 - 1086 WP_011148442.1 winged helix-turn-helix transcriptional regulator -
PluDJC_RS21610 4903544..4903720 + 177 WP_041381194.1 type II toxin-antitoxin system HicA family toxin Toxin
PluDJC_RS21615 4903772..4904179 + 408 WP_041380398.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PluDJC_RS21620 4904251..4904505 - 255 WP_011148445.1 cloacin immunity family protein -
PluDJC_RS21625 4904554..4905567 - 1014 WP_011148446.1 IS630-like element ISPlu10 family transposase -
PluDJC_RS21630 4905960..4907159 - 1200 WP_011148447.1 aspartate/tyrosine/aromatic aminotransferase -
PluDJC_RS21635 4907209..4908288 - 1080 WP_011148448.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4904554..4905567 1013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.95 Da        Isoelectric Point: 11.2826

>T89188 WP_041381194.1 NZ_CP024900:4903544-4903720 [Photorhabdus laumondii subsp. laumondii]
VKQSEFRRWLKAQGAEFKDGTNHLKVFLNGKQTTMPRHPSKEIPEPLRKLILKQPGIK

Download         Length: 177 bp

>T89188 NZ_CP024900:4903544-4903720 [Photorhabdus laumondii subsp. laumondii]
GTGAAGCAAAGCGAGTTTCGCCGGTGGCTTAAAGCTCAGGGAGCAGAATTCAAAGATGGGACTAACCACTTGAAAGTTTT
CCTGAACGGTAAGCAAACCACGATGCCAAGGCACCCTAGTAAAGAAATCCCAGAACCACTGAGGAAATTAATATTAAAAC
AGCCAGGCATCAAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14926.07 Da        Isoelectric Point: 4.7620

>AT89188 WP_041380398.1 NZ_CP024900:4903772-4904179 [Photorhabdus laumondii subsp. laumondii]
MRYPVKFEHDETGWAVMFPDIPEALTGGDTREEALAMAQDALVTAFDFYFEDRREIPTPSTKGEAFVEVPASIAAKVLLL
NTMLQTRTSNAELARLLGTRPQEIQRIVSLSHSTKIDTIANALNALGKHLELVAI

Download         Length: 408 bp

>AT89188 NZ_CP024900:4903772-4904179 [Photorhabdus laumondii subsp. laumondii]
ATGCGATATCCAGTAAAATTCGAACATGACGAAACAGGTTGGGCTGTGATGTTCCCAGATATCCCAGAAGCCTTAACAGG
CGGAGATACCAGAGAAGAAGCATTAGCTATGGCGCAGGATGCTCTGGTTACTGCGTTTGATTTCTACTTTGAAGACCGGC
GCGAAATACCAACACCATCGACTAAAGGTGAAGCTTTTGTCGAAGTACCAGCCAGTATAGCGGCTAAGGTTTTACTGTTG
AATACGATGCTTCAAACAAGAACAAGCAACGCAGAACTTGCACGGTTACTGGGAACTCGACCGCAAGAAATTCAACGTAT
AGTGTCATTAAGTCATAGCACTAAAATTGACACTATCGCGAATGCGTTAAATGCCTTGGGTAAACATCTGGAACTTGTTG
CCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JPT8

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JPT3

References