Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 982046..982829 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name TacT2 Uniprot ID Q7N879
Locus tag PluDJC_RS04405 Protein ID WP_011145230.1
Coordinates 982329..982829 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag PluDJC_RS04400 Protein ID WP_011145229.1
Coordinates 982046..982324 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS04375 977363..978529 - 1167 WP_011145224.1 cupin domain-containing protein -
PluDJC_RS04380 978689..979105 - 417 WP_192880152.1 hypothetical protein -
PluDJC_RS04390 980647..980910 + 264 WP_058588659.1 helix-turn-helix domain-containing protein -
PluDJC_RS04395 981280..981825 + 546 WP_011145228.1 hypoxanthine phosphoribosyltransferase -
PluDJC_RS04400 982046..982324 + 279 WP_011145229.1 DUF1778 domain-containing protein Antitoxin
PluDJC_RS04405 982329..982829 + 501 WP_011145230.1 GNAT family N-acetyltransferase Toxin
PluDJC_RS26510 983187..983651 + 465 WP_201742990.1 hypothetical protein -
PluDJC_RS04415 983930..984466 + 537 WP_109791350.1 hypoxanthine phosphoribosyltransferase -
PluDJC_RS04420 984575..984853 - 279 WP_011145233.1 HigA family addiction module antidote protein -
PluDJC_RS04425 984864..985145 - 282 WP_109791351.1 type II toxin-antitoxin system RelE/ParE family toxin -
PluDJC_RS04440 986469..987482 - 1014 WP_011144854.1 IS630-like element ISPlu10 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 986469..987482 1013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-142)

Antitoxin

Vibrio phage ICP1, Orf50

(5-92)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18532.23 Da        Isoelectric Point: 9.2491

>T89163 WP_011145230.1 NZ_CP024900:982329-982829 [Photorhabdus laumondii subsp. laumondii]
MINDPTLLTDDHNLNSFTSGIDTLDNWLTDRALKNQKENASRTYVVSEDRDVIAYYSLATGSIMSEEAISKFKRNMPNPI
PTIILGRLAVDKRYQGRGFGRYLVRDASIRVAQAADLVGVRGLIVHAISENAKAFYKSVGFSDSLLNPMTLMITLKDLKT
VFKITD

Download         Length: 501 bp

>T89163 NZ_CP024900:982329-982829 [Photorhabdus laumondii subsp. laumondii]
ATGATTAATGATCCAACCTTGTTAACAGATGATCACAATTTAAATAGTTTTACTTCAGGAATTGATACCCTAGACAACTG
GTTAACAGACAGAGCATTAAAAAATCAAAAAGAGAATGCTTCACGAACCTATGTTGTAAGCGAAGACAGAGATGTTATTG
CTTATTATTCGTTAGCGACCGGCTCAATTATGTCAGAAGAGGCGATAAGCAAGTTTAAGCGTAATATGCCAAATCCTATT
CCGACGATTATTTTGGGTCGCTTAGCTGTTGATAAGCGTTATCAAGGAAGAGGGTTTGGTCGCTATTTAGTTAGAGATGC
TTCCATACGTGTCGCTCAAGCGGCAGATTTGGTGGGTGTTAGGGGGTTGATTGTCCATGCTATCTCGGAGAATGCTAAGG
CATTTTATAAGTCTGTGGGTTTTAGTGATTCGCTTTTAAATCCAATGACGTTAATGATCACGCTAAAGGATTTAAAAACG
GTTTTTAAAATAACAGATTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10637.37 Da        Isoelectric Point: 10.2880

>AT89163 WP_011145229.1 NZ_CP024900:982046-982324 [Photorhabdus laumondii subsp. laumondii]
MNVISENRKNKTLNLRIRQEDRDLIDRAAKVKGKTVTEYVLDTIKRDAENTLLEHSFMIVSPEIFNAFIAKLDAPAVPNE
RLIKTANMKKPW

Download         Length: 279 bp

>AT89163 NZ_CP024900:982046-982324 [Photorhabdus laumondii subsp. laumondii]
ATGAACGTAATAAGTGAGAATCGTAAAAATAAGACACTCAACTTGAGGATTAGGCAAGAGGATCGGGATTTAATAGATAG
AGCAGCAAAAGTGAAGGGAAAAACCGTTACTGAATATGTCCTTGATACAATCAAACGTGATGCTGAAAACACGTTATTGG
AACATTCATTTATGATTGTATCTCCAGAAATTTTTAATGCTTTTATTGCTAAACTTGATGCTCCGGCTGTTCCAAATGAG
CGTCTTATCAAAACGGCAAATATGAAAAAACCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JXS3

Antitoxin

Source ID Structure

References