Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 984575..985145 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PluDJC_RS04425 Protein ID WP_109791351.1
Coordinates 984864..985145 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PluDJC_RS04420 Protein ID WP_011145233.1
Coordinates 984575..984853 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS04390 980647..980910 + 264 WP_058588659.1 helix-turn-helix domain-containing protein -
PluDJC_RS04395 981280..981825 + 546 WP_011145228.1 hypoxanthine phosphoribosyltransferase -
PluDJC_RS04400 982046..982324 + 279 WP_011145229.1 DUF1778 domain-containing protein -
PluDJC_RS04405 982329..982829 + 501 WP_011145230.1 GNAT family N-acetyltransferase -
PluDJC_RS26510 983187..983651 + 465 WP_201742990.1 hypothetical protein -
PluDJC_RS04415 983930..984466 + 537 WP_109791350.1 hypoxanthine phosphoribosyltransferase -
PluDJC_RS04420 984575..984853 - 279 WP_011145233.1 HigA family addiction module antidote protein Antitoxin
PluDJC_RS04425 984864..985145 - 282 WP_109791351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluDJC_RS04440 986469..987482 - 1014 WP_011144854.1 IS630-like element ISPlu10 family transposase -
PluDJC_RS04445 987851..988504 - 654 WP_011145235.1 carbonate dehydratase -
PluDJC_RS04450 988692..989603 + 912 WP_011145236.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 986469..987482 1013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10603.26 Da        Isoelectric Point: 10.4815

>T89164 WP_109791351.1 NZ_CP024900:c985145-984864 [Photorhabdus laumondii subsp. laumondii]
MIKSFKHKGLEKFFKTGSTAGIQPKHALKLQIQLTALNTAKKPEDMNAPSWKLHPLKGANLSGHWAISVNGNWRLTFRFE
GEDIILVNYQDYH

Download         Length: 282 bp

>T89164 NZ_CP024900:c985145-984864 [Photorhabdus laumondii subsp. laumondii]
ATGATTAAAAGCTTCAAACACAAAGGATTGGAAAAATTTTTCAAAACTGGTTCTACCGCTGGCATTCAGCCTAAGCATGC
CCTAAAGCTGCAAATCCAGCTAACTGCATTGAATACGGCTAAAAAACCAGAAGATATGAATGCCCCTAGCTGGAAACTTC
ACCCACTAAAAGGAGCAAATCTTAGCGGTCACTGGGCAATATCTGTTAACGGTAATTGGCGTTTAACATTTAGATTTGAG
GGCGAAGATATAATTCTCGTTAATTATCAAGATTATCACTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9992.63 Da        Isoelectric Point: 9.7351

>AT89164 WP_011145233.1 NZ_CP024900:c984853-984575 [Photorhabdus laumondii subsp. laumondii]
MKMHKPAHPGIVLREYLGDISVTEAAKALGITRAALSRILNGNAGISADMALRLEAALGTSAEMWTGMQSQYELWIASQH
KRPEIKPILAHS

Download         Length: 279 bp

>AT89164 NZ_CP024900:c984853-984575 [Photorhabdus laumondii subsp. laumondii]
ATGAAAATGCATAAACCTGCACACCCAGGCATAGTTTTGCGTGAATATCTTGGTGACATATCTGTCACGGAAGCAGCAAA
GGCTCTCGGTATAACCAGAGCTGCACTATCCCGCATATTAAACGGCAATGCAGGAATATCTGCTGATATGGCCCTGCGAC
TGGAAGCCGCATTAGGTACTAGTGCCGAAATGTGGACAGGAATGCAGTCCCAATATGAACTGTGGATTGCCTCACAGCAC
AAAAGACCAGAAATAAAACCAATACTGGCTCACTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References