Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5086809..5087444 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name hicA Uniprot ID Q7MZD9
Locus tag A4R40_RS22305 Protein ID WP_041381194.1
Coordinates 5086809..5086985 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A4R40_RS22310 Protein ID WP_109791871.1
Coordinates 5087037..5087444 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS22295 5084094..5085032 - 939 WP_011148441.1 pseudouridine-5'-phosphate glycosidase -
A4R40_RS22300 5085035..5086120 - 1086 WP_011148442.1 winged helix-turn-helix transcriptional regulator -
A4R40_RS22305 5086809..5086985 + 177 WP_041381194.1 type II toxin-antitoxin system HicA family toxin Toxin
A4R40_RS22310 5087037..5087444 + 408 WP_109791871.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4R40_RS22315 5087516..5087770 - 255 WP_011148445.1 cloacin immunity family protein -
A4R40_RS22320 5087819..5088832 - 1014 WP_011148446.1 IS630-like element ISPlu10 family transposase -
A4R40_RS22325 5089225..5090424 - 1200 WP_011148447.1 aspartate/tyrosine/aromatic aminotransferase -
A4R40_RS22330 5090474..5091553 - 1080 WP_011148448.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5085035..5106807 21772
flank IS/Tn - - 5087819..5088832 1013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.95 Da        Isoelectric Point: 11.2826

>T62862 WP_041381194.1 NZ_CP015281:5086809-5086985 [Photorhabdus laumondii subsp. laumondii]
VKQSEFRRWLKAQGAEFKDGTNHLKVFLNGKQTTMPRHPSKEIPEPLRKLILKQPGIK

Download         Length: 177 bp

>T62862 NZ_CP015281:5086809-5086985 [Photorhabdus laumondii subsp. laumondii]
GTGAAGCAAAGCGAGTTTCGCCGGTGGCTTAAAGCTCAGGGAGCAGAATTCAAAGATGGGACTAACCACTTGAAAGTTTT
CCTGAACGGTAAGCAAACCACGATGCCAAGGCACCCTAGTAAAGAAATCCCAGAACCACTGAGGAAATTAATATTAAAAC
AGCCAGGCATCAAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14940.10 Da        Isoelectric Point: 4.7620

>AT62862 WP_109791871.1 NZ_CP015281:5087037-5087444 [Photorhabdus laumondii subsp. laumondii]
MRYPVKFEHDETGWAVMFPDIPEALTGGDTREEALAMAQDALVTAFDFYFEDRREIPTPSTKGEAFVEVPASIAAKVLLL
NTMLQTRTSNAELARLLGTRPQEIQRIVSLSHSTKIDTIANALNALAKHLELVAI

Download         Length: 408 bp

>AT62862 NZ_CP015281:5087037-5087444 [Photorhabdus laumondii subsp. laumondii]
ATGCGATATCCAGTAAAATTCGAACATGACGAAACAGGTTGGGCTGTGATGTTCCCAGATATCCCAGAAGCCTTAACAGG
CGGAGATACCAGAGAAGAAGCATTAGCTATGGCGCAGGATGCTCTGGTTACTGCGTTTGATTTCTACTTTGAAGACCGGC
GCGAAATACCAACACCATCGACTAAAGGTGAAGCTTTTGTCGAAGTACCAGCCAGTATAGCGGCTAAGGTTTTACTGTTG
AATACGATGCTTCAAACAAGAACAAGCAACGCAGAACTTGCACGGTTACTGGGAACTCGACCGCAAGAAATTCAACGTAT
AGTGTCATTAAGTCATAGCACTAAAATTGACACTATCGCGAATGCGTTAAATGCCTTGGCTAAACATCTGGAACTTGTTG
CCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JPT8

Antitoxin

Source ID Structure

References