21013

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4086678..4087315 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name hicA Uniprot ID Q7N1I2
Locus tag PLU_RS17330 Protein ID WP_011147672.1
Coordinates 4087142..4087315 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1B8YHV7
Locus tag PLU_RS17325 Protein ID WP_036808644.1
Coordinates 4086678..4087088 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS17290 (plu3483) 4082277..4082774 + 498 WP_011147663.1 siphovirus Gp157 family protein -
PLU_RS17295 (plu3484) 4082826..4083014 + 189 WP_011147664.1 hypothetical protein -
PLU_RS27405 (plu3485) 4083584..4083754 + 171 WP_011147665.1 hypothetical protein -
PLU_RS17300 (plu3486) 4083759..4083974 + 216 WP_011147666.1 hypothetical protein -
PLU_RS17305 (plu3487) 4083926..4085109 + 1184 Protein_3446 DUF3596 domain-containing protein -
PLU_RS17310 (plu3488) 4085555..4085770 - 216 WP_049789790.1 hypothetical protein -
PLU_RS17315 (plu3489) 4085834..4086064 + 231 WP_011147669.1 hypothetical protein -
PLU_RS17320 (plu3490) 4086061..4086330 + 270 WP_011147670.1 helix-turn-helix domain-containing protein -
PLU_RS17325 (plu3491) 4086678..4087088 - 411 WP_036808644.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PLU_RS17330 (plu3492) 4087142..4087315 - 174 WP_011147672.1 type II toxin-antitoxin system HicA family toxin Toxin
PLU_RS17335 (plu3494) 4087435..4089083 - 1649 Protein_3452 hypothetical protein -
PLU_RS17340 (plu3495) 4089083..4089619 - 537 WP_041380260.1 hypothetical protein -
PLU_RS17345 (plu3496) 4089591..4090199 - 609 WP_011147676.1 hypothetical protein -
PLU_RS17350 (plu3497) 4090319..4090938 - 620 Protein_3455 tail fiber assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4007219..4096355 89136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6680.79 Da        Isoelectric Point: 11.3427

>T21013 WP_011147672.1 NC_005126:c4087315-4087142 [Photorhabdus laumondii subsp. laumondii TTO1]
VKQSEFRRWLEAQGVEVSNGTNHLKLRYQGKRSIMPRHPSQEIKEPLRKAIIKQLGL

Download         Length: 174 bp

>T21013 NC_005126:c4087315-4087142 [Photorhabdus laumondii subsp. laumondii TTO1]
GTGAAGCAAAGCGAGTTTAGACGGTGGCTGGAAGCTCAAGGCGTCGAAGTTTCAAATGGGACAAACCATCTGAAACTGAG
ATACCAGGGGAAACGAAGCATTATGCCGAGACACCCTAGCCAAGAGATCAAAGAGCCGCTGAGGAAAGCAATCATTAAGC
AATTAGGATTGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15131.32 Da        Isoelectric Point: 4.2783

>AT21013 WP_036808644.1 NC_005126:c4087088-4086678 [Photorhabdus laumondii subsp. laumondii TTO1]
MRYPVTLEPVEEGGYFVSFPDIPEALTQGDTREEALEMALDALITAFEFYFEDNEKIPLPGPVGQDYVDVPLSVASKVLM
LNAFLDSKLTQIELANRMGVKKQEVTRIFDLRHSTKIDTVGKVASAIGHQLTLSIE

Download         Length: 411 bp

>AT21013 NC_005126:c4087088-4086678 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGCGATATCCAGTCACACTAGAGCCAGTAGAAGAGGGCGGTTATTTCGTCTCATTCCCGGATATCCCCGAAGCTTTAAC
CCAGGGGGATACACGGGAAGAGGCGCTAGAGATGGCACTCGATGCGCTAATAACCGCTTTTGAATTTTACTTCGAAGATA
ATGAAAAAATCCCGCTTCCTGGCCCCGTAGGGCAGGATTATGTTGATGTGCCCTTAAGCGTGGCCTCTAAGGTGCTTATG
CTCAATGCGTTTCTTGATTCCAAGTTAACGCAAATTGAATTAGCCAACCGTATGGGGGTGAAAAAGCAGGAAGTGACCCG
TATCTTTGATTTACGGCACTCAACTAAAATTGATACGGTGGGTAAGGTCGCATCGGCTATCGGACATCAGTTAACTTTGT
CCATTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JNW7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8YHV7

References