Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4086676..4087313 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name hicA Uniprot ID Q7N1I2
Locus tag A4R40_RS17990 Protein ID WP_011147672.1
Coordinates 4087140..4087313 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A4R40_RS17985 Protein ID WP_109791736.1
Coordinates 4086676..4087086 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS17950 4082275..4082772 + 498 WP_011147663.1 siphovirus Gp157 family protein -
A4R40_RS17955 4082824..4083012 + 189 WP_011147664.1 hypothetical protein -
A4R40_RS26125 4083582..4083752 + 171 WP_011147665.1 hypothetical protein -
A4R40_RS17960 4083757..4083972 + 216 WP_011147666.1 hypothetical protein -
A4R40_RS17965 4083924..4085107 + 1184 Protein_3434 DUF3596 domain-containing protein -
A4R40_RS26135 4085553..4085768 - 216 WP_049789790.1 hypothetical protein -
A4R40_RS17975 4085832..4086062 + 231 WP_011147669.1 hypothetical protein -
A4R40_RS17980 4086059..4086328 + 270 WP_011147670.1 helix-turn-helix domain-containing protein -
A4R40_RS17985 4086676..4087086 - 411 WP_109791736.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4R40_RS17990 4087140..4087313 - 174 WP_011147672.1 type II toxin-antitoxin system HicA family toxin Toxin
A4R40_RS17995 4087433..4089081 - 1649 Protein_3440 hypothetical protein -
A4R40_RS18000 4089081..4089617 - 537 WP_041380260.1 hypothetical protein -
A4R40_RS18005 4089589..4090197 - 609 WP_011147676.1 hypothetical protein -
A4R40_RS18010 4090317..4090936 - 620 Protein_3443 tail fiber assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4007649..4096353 88704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6680.79 Da        Isoelectric Point: 11.3427

>T62854 WP_011147672.1 NZ_CP015281:c4087313-4087140 [Photorhabdus laumondii subsp. laumondii]
VKQSEFRRWLEAQGVEVSNGTNHLKLRYQGKRSIMPRHPSQEIKEPLRKAIIKQLGL

Download         Length: 174 bp

>T62854 NZ_CP015281:c4087313-4087140 [Photorhabdus laumondii subsp. laumondii]
GTGAAGCAAAGCGAGTTTAGACGGTGGCTGGAAGCTCAAGGCGTCGAAGTTTCAAATGGGACAAACCATCTGAAACTGAG
ATACCAAGGGAAACGAAGCATTATGCCGAGACACCCTAGCCAAGAGATCAAAGAGCCGCTGAGGAAAGCAATCATTAAGC
AATTAGGATTGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15103.26 Da        Isoelectric Point: 4.2783

>AT62854 WP_109791736.1 NZ_CP015281:c4087086-4086676 [Photorhabdus laumondii subsp. laumondii]
MRYPVTLEPVEEGGYFVSFPDIPEALTQGDTREEALEMALDALITAFEFYFEDNEKIPLPGPAGQDYVDVPLSVASKVLM
LNAFLDSKLTQIELANRMGVKKQEVTRIFDLRHSTKIDTVGKVASAIGHQLTLSIE

Download         Length: 411 bp

>AT62854 NZ_CP015281:c4087086-4086676 [Photorhabdus laumondii subsp. laumondii]
ATGCGATATCCAGTCACACTAGAGCCAGTAGAAGAGGGCGGTTATTTCGTCTCATTCCCGGATATCCCCGAAGCTTTAAC
CCAGGGGGATACACGGGAAGAGGCGCTAGAGATGGCACTCGATGCGCTAATAACCGCTTTTGAATTTTACTTCGAAGATA
ATGAAAAAATCCCGCTTCCTGGCCCCGCAGGGCAGGATTATGTTGATGTGCCCTTAAGCGTGGCCTCTAAGGTGCTTATG
CTCAATGCGTTTCTTGATTCCAAGTTAACGCAAATTGAATTAGCCAACCGTATGGGGGTGAAAAAGCAGGAAGTGACCCG
TATCTTTGATTTACGGCACTCAACTAAAATTGATACGGTGGGTAAGGTCGCATCGGCTATCGGACATCAGTTAACTTTGT
CCATTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JNW7

Antitoxin

Source ID Structure

References