Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2733991..2734686 Replicon chromosome
Accession NC_004668
Organism Enterococcus faecalis V583

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag EF_RS13505 Protein ID WP_002385632.1
Coordinates 2734342..2734686 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag EF_RS13500 Protein ID WP_002385633.1
Coordinates 2733991..2734323 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EF_RS13450 (EF2840) 2729353..2730168 - 816 WP_002393795.1 PD-(D/E)XK nuclease-like domain-containing protein -
EF_RS13455 (EF2841) 2730131..2731147 - 1017 WP_002393794.1 RecT family recombinase -
EF_RS13460 (EF2843) 2731250..2731474 - 225 WP_002370012.1 hypothetical protein -
EF_RS13465 (EF2844) 2731471..2731770 - 300 WP_002385643.1 hypothetical protein -
EF_RS13470 (EF2845) 2731837..2732016 - 180 WP_010785685.1 hypothetical protein -
EF_RS13475 (EF2846) 2732052..2732321 - 270 WP_002385641.1 hypothetical protein -
EF_RS13480 (EF2847) 2732397..2732711 + 315 WP_002385638.1 hypothetical protein -
EF_RS16955 (EF2848) 2732692..2732820 - 129 WP_002385637.1 hypothetical protein -
EF_RS13485 (EF2849) 2732836..2733012 - 177 WP_002385636.1 helix-turn-helix transcriptional regulator -
EF_RS13490 (EF2850) 2733096..2733479 + 384 WP_002385635.1 DUF2513 domain-containing protein -
EF_RS13495 (EF2851) 2733476..2733685 - 210 WP_002415277.1 DUF2829 domain-containing protein -
EF_RS13500 (EF2852) 2733991..2734323 + 333 WP_002385633.1 helix-turn-helix transcriptional regulator Antitoxin
EF_RS13505 (EF2853) 2734342..2734686 + 345 WP_002385632.1 ImmA/IrrE family metallo-endopeptidase Toxin
EF_RS13510 (EF2854) 2734744..2735472 + 729 WP_002385631.1 potassium channel family protein -
EF_RS13515 (EF2855) 2735627..2736808 + 1182 WP_010774242.1 site-specific integrase -
EF_RS13520 (EF2856) 2736911..2737060 - 150 WP_002356321.1 50S ribosomal protein L33 -
EF_RS13525 (EF2857) 2737186..2739321 - 2136 WP_010706862.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2703543..2736808 33265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6229

>T20903 WP_002385632.1 NC_004668:2734342-2734686 [Enterococcus faecalis V583]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

>T20903 NC_004668:2734342-2734686 [Enterococcus faecalis V583]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAAAAGAACATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12677.13 Da        Isoelectric Point: 4.6211

>AT20903 WP_002385633.1 NC_004668:2733991-2734323 [Enterococcus faecalis V583]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT20903 NC_004668:2733991-2734323 [Enterococcus faecalis V583]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGACGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References