259743

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 634430..635125 Replicon chromosome
Accession NZ_CP106757
Organism Enterococcus faecalis strain NY13410

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag N8I78_RS03005 Protein ID WP_002385632.1
Coordinates 634430..634774 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag N8I78_RS03010 Protein ID WP_002385633.1
Coordinates 634793..635125 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8I78_RS02985 (629795) 629795..631930 + 2136 WP_010706862.1 penicillin-binding protein 2 -
N8I78_RS02990 (632056) 632056..632205 + 150 WP_002356321.1 50S ribosomal protein L33 -
N8I78_RS02995 (632308) 632308..633489 - 1182 WP_010714109.1 site-specific integrase -
N8I78_RS03000 (633644) 633644..634372 - 729 WP_002385631.1 potassium channel family protein -
N8I78_RS03005 (634430) 634430..634774 - 345 WP_002385632.1 ImmA/IrrE family metallo-endopeptidase Toxin
N8I78_RS03010 (634793) 634793..635125 - 333 WP_002385633.1 helix-turn-helix transcriptional regulator Antitoxin
N8I78_RS03015 (635431) 635431..635640 + 210 WP_002415277.1 DUF2829 domain-containing protein -
N8I78_RS03020 (635637) 635637..636020 - 384 WP_002385635.1 DUF2513 domain-containing protein -
N8I78_RS03025 (636104) 636104..636280 + 177 WP_002385636.1 helix-turn-helix transcriptional regulator -
N8I78_RS03030 (636296) 636296..636424 + 129 WP_002385637.1 hypothetical protein -
N8I78_RS03035 (636405) 636405..636719 - 315 WP_002385638.1 hypothetical protein -
N8I78_RS03040 (636795) 636795..637064 + 270 WP_002385641.1 hypothetical protein -
N8I78_RS03045 (637100) 637100..637279 + 180 WP_010785685.1 hypothetical protein -
N8I78_RS03050 (637346) 637346..637645 + 300 WP_002385643.1 hypothetical protein -
N8I78_RS03055 (637642) 637642..637866 + 225 WP_002370012.1 hypothetical protein -
N8I78_RS03060 (637969) 637969..638985 + 1017 WP_002393794.1 RecT family recombinase -
N8I78_RS03065 (638948) 638948..639763 + 816 WP_002393795.1 PD-(D/E)XK nuclease-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 632308..680573 48265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6229

>T259743 WP_002385632.1 NZ_CP106757:c634774-634430 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12677.13 Da        Isoelectric Point: 4.6211

>AT259743 WP_002385633.1 NZ_CP106757:c635125-634793 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References