129089

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2625109..2625804 Replicon chromosome
Accession NZ_CP041738
Organism Enterococcus faecalis EnGen0107 strain B594

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag SAW_RS13835 Protein ID WP_002385632.1
Coordinates 2625460..2625804 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag SAW_RS13830 Protein ID WP_002385633.1
Coordinates 2625109..2625441 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAW_RS13770 2620471..2621286 - 816 WP_002393795.1 PD-(D/E)XK nuclease-like domain-containing protein -
SAW_RS13775 2621249..2622265 - 1017 WP_002393794.1 recombinase RecT -
SAW_RS13785 2622368..2622592 - 225 WP_002370012.1 hypothetical protein -
SAW_RS13790 2622589..2622888 - 300 WP_002385643.1 hypothetical protein -
SAW_RS13795 2622955..2623134 - 180 WP_010785685.1 hypothetical protein -
SAW_RS13800 2623170..2623439 - 270 WP_002385641.1 hypothetical protein -
SAW_RS13805 2623515..2623829 + 315 WP_002385638.1 hypothetical protein -
SAW_RS13815 2623954..2624130 - 177 WP_002385636.1 helix-turn-helix domain-containing protein -
SAW_RS13820 2624214..2624597 + 384 WP_002385635.1 DUF2513 domain-containing protein -
SAW_RS13825 2624594..2624812 - 219 WP_002385634.1 DUF2829 domain-containing protein -
SAW_RS13830 2625109..2625441 + 333 WP_002385633.1 helix-turn-helix domain-containing protein Antitoxin
SAW_RS13835 2625460..2625804 + 345 WP_002385632.1 ImmA/IrrE family metallo-endopeptidase Toxin
SAW_RS13840 2625862..2626590 + 729 WP_002385631.1 potassium channel family protein -
SAW_RS13845 2626745..2627926 + 1182 WP_010714109.1 site-specific integrase -
SAW_RS13850 2628029..2628178 - 150 WP_002356321.1 50S ribosomal protein L33 -
SAW_RS13855 2628304..2630439 - 2136 WP_010706862.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2585918..2627926 42008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6229

>T129089 WP_002385632.1 NZ_CP041738:2625460-2625804 [Enterococcus faecalis EnGen0107]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

>T129089 NZ_CP041738:2625460-2625804 [Enterococcus faecalis EnGen0107]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAAAAGAACATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12677.13 Da        Isoelectric Point: 4.6211

>AT129089 WP_002385633.1 NZ_CP041738:2625109-2625441 [Enterococcus faecalis EnGen0107]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT129089 NZ_CP041738:2625109-2625441 [Enterococcus faecalis EnGen0107]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGACGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References