151546

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2361557..2362252 Replicon chromosome
Accession NZ_CP049775
Organism Enterococcus faecalis strain ES-1

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag G7X26_RS11520 Protein ID WP_002385632.1
Coordinates 2361908..2362252 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag G7X26_RS11515 Protein ID WP_002385633.1
Coordinates 2361557..2361889 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7X26_RS11465 2356919..2357734 - 816 WP_002393795.1 PD-(D/E)XK nuclease-like domain-containing protein -
G7X26_RS11470 2357697..2358713 - 1017 WP_002393794.1 recombinase RecT -
G7X26_RS11475 2358816..2359040 - 225 WP_002370012.1 hypothetical protein -
G7X26_RS11480 2359037..2359336 - 300 WP_002385643.1 hypothetical protein -
G7X26_RS11485 2359403..2359582 - 180 WP_010785685.1 hypothetical protein -
G7X26_RS11490 2359618..2359887 - 270 WP_002385641.1 hypothetical protein -
G7X26_RS11495 2359963..2360277 + 315 WP_002385638.1 hypothetical protein -
G7X26_RS11500 2360402..2360578 - 177 WP_002385636.1 helix-turn-helix domain-containing protein -
G7X26_RS11505 2360662..2361045 + 384 WP_159110597.1 DUF2513 domain-containing protein -
G7X26_RS11510 2361042..2361260 - 219 WP_002385634.1 DUF2829 domain-containing protein -
G7X26_RS11515 2361557..2361889 + 333 WP_002385633.1 helix-turn-helix domain-containing protein Antitoxin
G7X26_RS11520 2361908..2362252 + 345 WP_002385632.1 ImmA/IrrE family metallo-endopeptidase Toxin
G7X26_RS11525 2362310..2363038 + 729 WP_002385631.1 potassium channel family protein -
G7X26_RS11530 2363193..2364374 + 1182 WP_010714109.1 site-specific integrase -
G7X26_RS11535 2364477..2364626 - 150 WP_002356321.1 50S ribosomal protein L33 -
G7X26_RS11540 2364752..2366887 - 2136 WP_165548655.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2331108..2364374 33266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6229

>T151546 WP_002385632.1 NZ_CP049775:2361908-2362252 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

>T151546 NZ_CP065607:c4536521-4536414 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12677.13 Da        Isoelectric Point: 4.6211

>AT151546 WP_002385633.1 NZ_CP049775:2361557-2361889 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT151546 NZ_CP065607:4536568-4536634 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References