Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2734274..2734969 Replicon chromosome
Accession NZ_CP039296
Organism Enterococcus faecalis strain VE14089

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag E7T02_RS14530 Protein ID WP_002385632.1
Coordinates 2734625..2734969 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag E7T02_RS14525 Protein ID WP_002385633.1
Coordinates 2734274..2734606 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E7T02_RS14465 2729636..2730451 - 816 WP_002393795.1 PD-(D/E)XK nuclease-like domain-containing protein -
E7T02_RS14470 2730414..2731430 - 1017 WP_002393794.1 recombinase RecT -
E7T02_RS14480 2731533..2731757 - 225 WP_002370012.1 hypothetical protein -
E7T02_RS14485 2731754..2732053 - 300 WP_002385643.1 hypothetical protein -
E7T02_RS14490 2732120..2732299 - 180 WP_010785685.1 hypothetical protein -
E7T02_RS14495 2732335..2732604 - 270 WP_002385641.1 hypothetical protein -
E7T02_RS14500 2732680..2732994 + 315 WP_002385638.1 hypothetical protein -
E7T02_RS14510 2733119..2733295 - 177 WP_002385636.1 helix-turn-helix domain-containing protein -
E7T02_RS14515 2733379..2733762 + 384 WP_002385635.1 DUF2513 domain-containing protein -
E7T02_RS14520 2733759..2733977 - 219 WP_002385634.1 DUF2829 domain-containing protein -
E7T02_RS14525 2734274..2734606 + 333 WP_002385633.1 helix-turn-helix domain-containing protein Antitoxin
E7T02_RS14530 2734625..2734969 + 345 WP_002385632.1 ImmA/IrrE family metallo-endopeptidase Toxin
E7T02_RS14535 2735027..2735755 + 729 WP_002385631.1 potassium channel family protein -
E7T02_RS14540 2735910..2737091 + 1182 WP_010774242.1 site-specific integrase -
E7T02_RS14545 2737194..2737343 - 150 WP_002356321.1 50S ribosomal protein L33 -
E7T02_RS14550 2737469..2739724 - 2256 WP_002387219.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2703826..2737091 33265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6229

>T123752 WP_002385632.1 NZ_CP039296:2734625-2734969 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

>T123752 NZ_CP039296:2734625-2734969 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAAAAGAACATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12677.13 Da        Isoelectric Point: 4.6211

>AT123752 WP_002385633.1 NZ_CP039296:2734274-2734606 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT123752 NZ_CP039296:2734274-2734606 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGACGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References