Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
Location | 2734274..2734969 | Replicon | chromosome |
Accession | NZ_CP039296 | ||
Organism | Enterococcus faecalis strain VE14089 |
Toxin (Protein)
Gene name | IrrE | Uniprot ID | - |
Locus tag | E7T02_RS14530 | Protein ID | WP_002385632.1 |
Coordinates | 2734625..2734969 (+) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | ImmA | Uniprot ID | - |
Locus tag | E7T02_RS14525 | Protein ID | WP_002385633.1 |
Coordinates | 2734274..2734606 (+) | Length | 111 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E7T02_RS14465 | 2729636..2730451 | - | 816 | WP_002393795.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
E7T02_RS14470 | 2730414..2731430 | - | 1017 | WP_002393794.1 | recombinase RecT | - |
E7T02_RS14480 | 2731533..2731757 | - | 225 | WP_002370012.1 | hypothetical protein | - |
E7T02_RS14485 | 2731754..2732053 | - | 300 | WP_002385643.1 | hypothetical protein | - |
E7T02_RS14490 | 2732120..2732299 | - | 180 | WP_010785685.1 | hypothetical protein | - |
E7T02_RS14495 | 2732335..2732604 | - | 270 | WP_002385641.1 | hypothetical protein | - |
E7T02_RS14500 | 2732680..2732994 | + | 315 | WP_002385638.1 | hypothetical protein | - |
E7T02_RS14510 | 2733119..2733295 | - | 177 | WP_002385636.1 | helix-turn-helix domain-containing protein | - |
E7T02_RS14515 | 2733379..2733762 | + | 384 | WP_002385635.1 | DUF2513 domain-containing protein | - |
E7T02_RS14520 | 2733759..2733977 | - | 219 | WP_002385634.1 | DUF2829 domain-containing protein | - |
E7T02_RS14525 | 2734274..2734606 | + | 333 | WP_002385633.1 | helix-turn-helix domain-containing protein | Antitoxin |
E7T02_RS14530 | 2734625..2734969 | + | 345 | WP_002385632.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
E7T02_RS14535 | 2735027..2735755 | + | 729 | WP_002385631.1 | potassium channel family protein | - |
E7T02_RS14540 | 2735910..2737091 | + | 1182 | WP_010774242.1 | site-specific integrase | - |
E7T02_RS14545 | 2737194..2737343 | - | 150 | WP_002356321.1 | 50S ribosomal protein L33 | - |
E7T02_RS14550 | 2737469..2739724 | - | 2256 | WP_002387219.1 | penicillin-binding protein 2 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2703826..2737091 | 33265 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13594.61 Da Isoelectric Point: 5.6229
>T123752 WP_002385632.1 NZ_CP039296:2734625-2734969 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKEHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK
Download Length: 345 bp
>T123752 NZ_CP039296:2734625-2734969 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAAAAGAACATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAAAAGAACATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12677.13 Da Isoelectric Point: 4.6211
>AT123752 WP_002385633.1 NZ_CP039296:2734274-2734606 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT123752 NZ_CP039296:2734274-2734606 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGACGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGACGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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