Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 867307..867784 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MW_RS04200 Protein ID WP_000052076.1
Coordinates 867307..867495 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MW_RS04205 Protein ID WP_001059690.1
Coordinates 867524..867784 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS04170 (MW0768) 863297..863818 + 522 WP_000824464.1 hypothetical protein -
MW_RS04175 (MW0769) 864159..864845 + 687 WP_001793574.1 thermonuclease family protein -
MW_RS04180 (MW0770) 865202..865402 + 201 WP_001059082.1 cold-shock protein -
MW_RS04185 (MW0771) 865898..866116 - 219 WP_000005886.1 hypothetical protein -
MW_RS04190 (MW0772) 866178..866462 - 285 WP_001004401.1 hypothetical protein -
MW_RS04195 (MW0773) 866550..867119 - 570 WP_001106654.1 hypothetical protein -
MW_RS04200 (MW0774) 867307..867495 - 189 WP_000052076.1 hypothetical protein Toxin
MW_RS04205 (MW0775) 867524..867784 - 261 WP_001059690.1 hypothetical protein Antitoxin
MW_RS04210 (MW0776) 868124..868327 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MW_RS04215 (MW0777) 868324..868560 - 237 WP_000368687.1 hypothetical protein -
MW_RS04220 (MW0778) 868784..869365 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
MW_RS04225 (MW0779) 869438..870055 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
MW_RS04230 (MW0780) 870210..870704 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MW_RS04235 (MW0781) 871103..871525 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
MW_RS04240 (MW0782) 871673..872389 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - sec / sell / clfA / vWbp / vWbp 836064..878267 42203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T20726 WP_000052076.1 NC_003923:c867495-867307 [Staphylococcus aureus subsp. aureus MW2]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T20726 NC_003923:c867495-867307 [Staphylococcus aureus subsp. aureus MW2]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT20726 WP_001059690.1 NC_003923:c867784-867524 [Staphylococcus aureus subsp. aureus MW2]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT20726 NC_003923:c867784-867524 [Staphylococcus aureus subsp. aureus MW2]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References