Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 867307..867784 | Replicon | chromosome |
Accession | NC_003923 | ||
Organism | Staphylococcus aureus subsp. aureus MW2 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | MW_RS04200 | Protein ID | WP_000052076.1 |
Coordinates | 867307..867495 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | MW_RS04205 | Protein ID | WP_001059690.1 |
Coordinates | 867524..867784 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MW_RS04170 (MW0768) | 863297..863818 | + | 522 | WP_000824464.1 | hypothetical protein | - |
MW_RS04175 (MW0769) | 864159..864845 | + | 687 | WP_001793574.1 | thermonuclease family protein | - |
MW_RS04180 (MW0770) | 865202..865402 | + | 201 | WP_001059082.1 | cold-shock protein | - |
MW_RS04185 (MW0771) | 865898..866116 | - | 219 | WP_000005886.1 | hypothetical protein | - |
MW_RS04190 (MW0772) | 866178..866462 | - | 285 | WP_001004401.1 | hypothetical protein | - |
MW_RS04195 (MW0773) | 866550..867119 | - | 570 | WP_001106654.1 | hypothetical protein | - |
MW_RS04200 (MW0774) | 867307..867495 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
MW_RS04205 (MW0775) | 867524..867784 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
MW_RS04210 (MW0776) | 868124..868327 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
MW_RS04215 (MW0777) | 868324..868560 | - | 237 | WP_000368687.1 | hypothetical protein | - |
MW_RS04220 (MW0778) | 868784..869365 | + | 582 | WP_001140696.1 | phosphoglycerate mutase family protein | - |
MW_RS04225 (MW0779) | 869438..870055 | - | 618 | WP_000255544.1 | LysE/ArgO family amino acid transporter | - |
MW_RS04230 (MW0780) | 870210..870704 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
MW_RS04235 (MW0781) | 871103..871525 | - | 423 | WP_000974464.1 | organic hydroperoxide resistance protein | - |
MW_RS04240 (MW0782) | 871673..872389 | + | 717 | WP_000150012.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | sec / sell / clfA / vWbp / vWbp | 836064..878267 | 42203 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T20726 WP_000052076.1 NC_003923:c867495-867307 [Staphylococcus aureus subsp. aureus MW2]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T20726 NC_003923:c867495-867307 [Staphylococcus aureus subsp. aureus MW2]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT20726 WP_001059690.1 NC_003923:c867784-867524 [Staphylococcus aureus subsp. aureus MW2]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT20726 NC_003923:c867784-867524 [Staphylococcus aureus subsp. aureus MW2]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |