Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1255309..1255786 Replicon chromosome
Accession NZ_CP026073
Organism Staphylococcus aureus strain FDAARGOS_42

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RL00_RS06670 Protein ID WP_000052076.1
Coordinates 1255598..1255786 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RL00_RS06665 Protein ID WP_001059690.1
Coordinates 1255309..1255569 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL00_RS06630 1250704..1251420 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
RL00_RS06635 1251568..1251990 + 423 WP_000974464.1 organic hydroperoxide resistance protein -
RL00_RS06640 1252389..1252883 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RL00_RS06645 1253038..1253655 + 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
RL00_RS06650 1253728..1254309 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
RL00_RS06655 1254533..1254769 + 237 WP_000368687.1 hypothetical protein -
RL00_RS06660 1254766..1254969 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RL00_RS06665 1255309..1255569 + 261 WP_001059690.1 hypothetical protein Antitoxin
RL00_RS06670 1255598..1255786 + 189 WP_000052076.1 hypothetical protein Toxin
RL00_RS06675 1255974..1256543 + 570 WP_001106654.1 hypothetical protein -
RL00_RS06680 1256631..1256915 + 285 WP_001004401.1 hypothetical protein -
RL00_RS06685 1256977..1257195 + 219 WP_000005886.1 hypothetical protein -
RL00_RS06690 1257691..1257891 - 201 WP_001059082.1 cold-shock protein -
RL00_RS06695 1258248..1258934 - 687 WP_001793574.1 thermonuclease family protein -
RL00_RS06700 1259275..1259796 - 522 WP_000824464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - vWbp / vWbp / clfA / sell / sec 1252389..1287029 34640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T93150 WP_000052076.1 NZ_CP026073:1255598-1255786 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93150 NZ_CP026073:1255598-1255786 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93150 WP_001059690.1 NZ_CP026073:1255309-1255569 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93150 NZ_CP026073:1255309-1255569 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References