Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 861817..862294 Replicon chromosome
Accession NZ_CP019574
Organism Staphylococcus aureus strain USA400-0051

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAU400_RS04340 Protein ID WP_000052076.1
Coordinates 861817..862005 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAU400_RS04345 Protein ID WP_001059690.1
Coordinates 862034..862294 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAU400_RS04310 857807..858328 + 522 WP_000824464.1 hypothetical protein -
SAU400_RS04315 858669..859355 + 687 WP_001793574.1 thermonuclease family protein -
SAU400_RS04320 859712..859912 + 201 WP_001059082.1 cold-shock protein -
SAU400_RS04325 860408..860626 - 219 WP_000005886.1 hypothetical protein -
SAU400_RS04330 860688..860972 - 285 WP_001004401.1 hypothetical protein -
SAU400_RS04335 861060..861629 - 570 WP_001106654.1 hypothetical protein -
SAU400_RS04340 861817..862005 - 189 WP_000052076.1 hypothetical protein Toxin
SAU400_RS04345 862034..862294 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAU400_RS04350 862634..862837 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAU400_RS04355 862834..863070 - 237 WP_000368687.1 hypothetical protein -
SAU400_RS04360 863294..863875 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SAU400_RS04365 863971..864564 - 594 Protein_801 amino acid transporter -
SAU400_RS04370 864719..865213 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAU400_RS04375 865612..866034 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
SAU400_RS04380 866182..866898 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - sec / sell / clfA / vWbp / vWbp 830583..872628 42045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T72682 WP_000052076.1 NZ_CP019574:c862005-861817 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T72682 NZ_CP019574:c862005-861817 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT72682 WP_001059690.1 NZ_CP019574:c862294-862034 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT72682 NZ_CP019574:c862294-862034 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References